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@ARTICLE{Lu:127975,
      author       = {H. Lu and K. R. Clauser and W. L. Tam and J. Fröse$^*$ and
                      X. Ye and E. N. Eaton and F. Reinhardt and V. S. Donnenberg
                      and R. Bhargava and S. A. Carr and R. A. Weinberg},
      title        = {{A} breast cancer stem cell niche supported by juxtacrine
                      signalling from monocytes and macrophages.},
      journal      = {Nature cell biology},
      volume       = {16},
      number       = {11},
      issn         = {1476-4679},
      address      = {New York, NY},
      publisher    = {Nature America},
      reportid     = {DKFZ-2017-03997},
      pages        = {1105 - 1117},
      year         = {2014},
      abstract     = {The cell-biological program termed the
                      epithelial-mesenchymal transition (EMT) confers on cancer
                      cells mesenchymal traits and an ability to enter the cancer
                      stem cell (CSC) state. However, the interactions between
                      CSCs and their surrounding microenvironment are poorly
                      understood. Here we show that tumour-associated monocytes
                      and macrophages (TAMs) create a CSC niche through juxtacrine
                      signalling with CSCs. We performed quantitative proteomic
                      profiling and found that the EMT program upregulates the
                      expression of CD90, also known as Thy1, and EphA4, which
                      mediate the physical interactions of CSCs with TAMs by
                      directly binding with their respective counter-receptors on
                      these cells. In response, the EphA4 receptor on the
                      carcinoma cells activates Src and NF-κB. In turn, NF-κB in
                      the CSCs induces the secretion of a variety of cytokines
                      that serve to sustain the stem cell state. Indeed, admixed
                      macrophages enhance the CSC activities of carcinoma cells.
                      These findings underscore the significance of TAMs as
                      important components of the CSC niche.},
      keywords     = {NF-kappa B (NLM Chemicals)},
      cin          = {A190},
      ddc          = {570},
      cid          = {I:(DE-He78)A190-20160331},
      pnm          = {311 - Signalling pathways, cell and tumor biology
                      (POF3-311)},
      pid          = {G:(DE-HGF)POF3-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25266422},
      pmc          = {pmc:PMC4296514},
      doi          = {10.1038/ncb3041},
      url          = {https://inrepo02.dkfz.de/record/127975},
}