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@ARTICLE{Gengenbacher:131504,
      author       = {N. Gengenbacher$^*$ and M. Singhal$^*$ and H. Augustin$^*$},
      title        = {{P}reclinical mouse solid tumour models: status quo,
                      challenges and perspectives.},
      journal      = {Nature reviews / Cancer},
      volume       = {17},
      number       = {12},
      issn         = {1474-1768},
      address      = {London [u.a.]},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2017-06171},
      pages        = {751 - 765},
      year         = {2017},
      abstract     = {Oncology research in humans is limited to analytical and
                      observational studies for obvious ethical reasons, with
                      therapy-focused clinical trials being the one exception to
                      this rule. Preclinical mouse tumour models therefore serve
                      as an indispensable intermediate experimental model system
                      bridging more reductionist in vitro research with human
                      studies. Based on a systematic survey of preclinical mouse
                      tumour studies published in eight scientific journals in
                      2016, this Analysis provides an overview of how contemporary
                      preclinical mouse tumour biology research is pursued. It
                      thereby identifies some of the most important challenges in
                      this field and discusses potential ways in which preclinical
                      mouse tumour models could be improved for better relevance,
                      reproducibility and translatability.},
      subtyp        = {Review Article},
      cin          = {A190 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)A190-20160331 / I:(DE-He78)L101-20160331},
      pnm          = {311 - Signalling pathways, cell and tumor biology
                      (POF3-311)},
      pid          = {G:(DE-HGF)POF3-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29077691},
      doi          = {10.1038/nrc.2017.92},
      url          = {https://inrepo02.dkfz.de/record/131504},
}