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024 7 _ |a 10.1038/s41416-018-0011-3
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024 7 _ |a pmid:29555990
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024 7 _ |a 0007-0920
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024 7 _ |a 1532-1827
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024 7 _ |a altmetric:34589931
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037 _ _ |a DKFZ-2018-00443
041 _ _ |a eng
082 _ _ |a 610
100 1 _ |a Dixon-Suen, Suzanne C
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245 _ _ |a Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study.
260 _ _ |a Edinburgh
|c 2018
|b Nature Publ. Group
336 7 _ |a article
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520 _ _ |a Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias.We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms. Study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted height and risk were pooled using random-effects meta-analysis.Greater genetically predicted height was associated with increased ovarian cancer risk overall (pooled-OR (pOR) = 1.06; 95% CI: 1.01-1.11 per 5 cm increase in height), and separately for invasive (pOR = 1.06; 95% CI: 1.01-1.11) and borderline (pOR = 1.15; 95% CI: 1.02-1.29) tumours.Women with a genetic propensity to being taller have increased risk of ovarian cancer. This suggests genes influencing height are involved in pathways promoting ovarian carcinogenesis.
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700 1 _ |a Pearce, Celeste Leigh
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700 1 _ |a Zheng, Wei
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700 1 _ |a Group, Australian Ovarian Cancer Study
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700 1 _ |a Gentry-Maharaj, Aleksandra
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700 1 _ |a Wu, Anna H
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700 1 _ |a Tseng, Chiu-Chen
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700 1 _ |a Consortium, Ovarian Cancer Association
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773 _ _ |a 10.1038/s41416-018-0011-3
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