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      author       = {K. Imkeller$^*$ and H. Wardemann$^*$},
      title        = {{A}ssessing human {B} cell repertoire diversity and
      journal      = {Immunological reviews},
      volume       = {284},
      number       = {1},
      issn         = {0105-2896},
      address      = {Oxford},
      publisher    = {Wiley-Blackwell},
      reportid     = {DKFZ-2018-01306},
      pages        = {51 - 66},
      year         = {2018},
      abstract     = {A hallmark of the adaptive immune system is the specificity
                      of B cell and T cell responses. Mechanistically, this
                      feature relies on the fact that the two genes that encode B
                      cell and T cell antigen receptors are not germline encoded
                      and instead are assembled from a large number of small gene
                      segments during lymphocyte development. The underlying
                      somatic gene recombination process can generate a
                      quasi-unlimited repertoire of antigen receptors. The high
                      degree of diversity is essential to guarantee recognition of
                      nearly any antigenic structure to protect from the large
                      variety of potential invading pathogens and to keep the
                      balance with commensals. Due to the enormous complexity of
                      the antigen receptor repertoire, our understanding of its
                      actual size and functional convergence at the level of the
                      individual and the population is still limited. A better
                      understanding of the actual degree of diversity could help
                      to predict adaptive immune responses and would have wide
                      implications for the development of preventive and
                      therapeutic measures against infectious and autoimmune
                      diseases as well as cancer. Here, we discuss the recent
                      advances in the field with a specific focus on B cells and
                      the function of antibodies.},
      subtyp        = {Review Article},
      cin          = {D130},
      ddc          = {610},
      cid          = {I:(DE-He78)D130-20160331},
      pnm          = {314 - Tumor immunology (POF3-314)},
      pid          = {G:(DE-HGF)POF3-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29944762},
      doi          = {10.1111/imr.12670},
      url          = {https://inrepo02.dkfz.de/record/136868},