TY  - JOUR
AU  - Wang, Xiaoliang
AU  - Chan, Andrew T
AU  - Slattery, Martha L
AU  - Chang-Claude, Jenny
AU  - Potter, John D
AU  - Gallinger, Steven
AU  - Caan, Bette
AU  - Lampe, Johanna W
AU  - Newcomb, Polly A
AU  - Zubair, Niha
AU  - Hsu, Li
AU  - Schoen, Robert E
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
AU  - Le Marchand, Loic
AU  - Peters, Ulrike
AU  - White, Emily
TI  - Influence of Smoking, Body Mass Index, and Other Factors on the Preventive Effect of Nonsteroidal Anti-Inflammatory Drugs on Colorectal Cancer Risk.
JO  - Cancer research
VL  - 78
IS  - 16
SN  - 1538-7445
CY  - Philadelphia, Pa.
PB  - AACR
M1  - DKFZ-2018-01496
SP  - 4790 - 4799
PY  - 2018
AB  - Nonsteroidal anti-inflammatory drugs' (NSAID) use has consistently been associated with lower risk of colorectal cancer; however, studies showed inconsistent results on which cohort of individuals may benefit most. We performed multivariable logistic regression analysis to systematically test for the interaction between regular use of NSAIDs and other lifestyle and dietary factors on colorectal cancer risk among 11,894 cases and 15,999 controls. Fixed-effects meta-analyses were used for stratified analyses across studies for each risk factor and to summarize the estimates from interactions. Regular use of any NSAID, aspirin, or nonaspirin NSAIDs was significantly associated with a lower risk of colorectal cancer within almost all subgroups. However, smoking status and BMI were found to modify the NSAID-colorectal cancer association. Aspirin use was associated with a 29
LB  - PUB:(DE-HGF)16
C6  - pmid:29921691
C2  - pmc:PMC6095723
DO  - DOI:10.1158/0008-5472.CAN-18-0326
UR  - https://inrepo02.dkfz.de/record/137616
ER  -