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@ARTICLE{Campa:141291,
      author       = {D. Campa and M. Matarazzi$^*$ and W. Greenhalf and M.
                      Bijlsma and K.-U. Saum$^*$ and C. Pasquali and H. van
                      Laarhoven and A. Szentesi and F. Federici and P. Vodicka and
                      N. Funel and R. Pezzilli and H. B. Bueno-de-Mesquita and L.
                      Vodickova and D. Basso and O. Obazee$^*$ and T. Hackert and
                      P. Soucek and K. Cuk$^*$ and J. Kaiser and C. Sperti and M.
                      Lovecek and G. Capurso and B. Mohelnikova-Duchonova and
                      K.-T. Khaw and A.-K. König and J. Kupcinskas and R.
                      Kaaks$^*$ and F. Bambi and L. Archibugi and A. Mambrini and
                      G. M. Cavestro and S. Landi and P. Hegyi and J. R. Izbicki
                      and D. Gioffreda and C. F. Zambon and F. Tavano and R.
                      Talar-Wojnarowska and K. Jamroziak and T. J. Key and G. D.
                      Fave and O. Strobel and L. Jonaitis and A. Andriulli and R.
                      T. Lawlor and F. Pirozzi and V. Katzke$^*$ and C. Valsuani
                      and Y. K. Vashist and H. Brenner$^*$ and F. Canzian$^*$},
      title        = {{G}enetic determinants of telomere length and risk of
                      pancreatic cancer: a {PAND}o{RA} study.},
      journal      = {International journal of cancer},
      volume       = {144},
      number       = {6},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2018-01811},
      pages        = {1275-1283},
      year         = {2019},
      abstract     = {Telomere deregulation is a hallmark of cancer. Telomere
                      length measured in lymphocytes (LTL) has been shown to be a
                      risk marker for several cancers. For pancreatic ductal
                      adenocarcinoma (PDAC) consensus is lacking whether risk is
                      associated with long or short telomeres. Mendelian
                      randomization approaches have shown that a score built from
                      SNPs associated with LTL could be used as a robust risk
                      marker. We explored this approach in a large scale study
                      within the PANcreatic Disease ReseArch (PANDoRA) consortium.
                      We analyzed 10 SNPs (ZNF676-rs409627, TERT-rs2736100,
                      CTC1-rs3027234, DHX35-rs6028466, PXK-rs6772228,
                      NAF1-rs7675998, ZNF208-rs8105767, OBFC1-rs9420907,
                      ACYP2-rs11125529 and TERC-rs10936599) alone and combined in
                      a LTL genetic score ('teloscore', which explains $2.2\%$ of
                      the telomere variability) in relation to PDAC risk in 2,374
                      cases and 4,326 controls. We identified several associations
                      with PDAC risk, among which the strongest were with the
                      TERT-rs2736100 SNP (OR = 1.54; $95\%CI$ 1.35-1.76;
                      p = 1.54x10-10 ) and a novel one with the NAF1-rs7675998
                      SNP (OR = 0.80; $95\%CI$ 0.73-0.88; p = 1.87x10-6 ,
                      ptrend  = 3.27x10-7 ). The association of short LTL,
                      measured by the teloscore, with PDAC risk reached
                      genome-wide significance (p = 2.98x10-9 for highest vs.
                      lowest quintile; p = 1.82x10-10 as a continuous variable).
                      In conclusion, we present a novel genome-wide candidate SNP
                      for PDAC risk (TERT-rs2736100), a completely new signal
                      (NAF1-rs7675998) approaching genome-wide significance and we
                      report a strong association between the teloscore and risk
                      of pancreatic cancer, suggesting that telomeres are a
                      potential risk factor for pancreatic cancer. This article is
                      protected by copyright. All rights reserved.},
      cin          = {C055 / C070 / C120 / C020 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)C055-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)C120-20160331 / I:(DE-He78)C020-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30325019},
      doi          = {10.1002/ijc.31928},
      url          = {https://inrepo02.dkfz.de/record/141291},
}