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000141418 0247_ $$2ISSN$$a1097-0215
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000141418 037__ $$aDKFZ-2018-01924
000141418 041__ $$aeng
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000141418 1001_ $$aLin, Crystal$$b0
000141418 245__ $$aPre-diagnostic circulating insulin-like growth factor-I and bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition.
000141418 260__ $$aBognor Regis$$bWiley-Liss$$c2018
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000141418 520__ $$aPrevious in vitro and case-control studies have found an association between the insulin-like growth factor (IGF)-axis and bladder cancer risk. Circulating concentrations of IGF-I have also been found to be associated with an increased risk of several cancer types; however, the relationship between pre-diagnostic circulating IGF-I concentrations and bladder cancer has never been studied prospectively. We investigated the association of pre-diagnostic plasma concentrations of IGF-I with risk of overall bladder cancer and urothelial cell carcinoma (UCC) in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 843 men and women diagnosed with bladder cancer between 1992 and 2005 were matched with 843 controls by recruitment centre, sex, age at recruitment, date of blood collection, duration of follow-up, time of day and fasting status at blood collection using an incidence density sampling protocol. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression with adjustment for smoking status. No association was found between pre-diagnostic circulating IGF-I concentration and overall bladder cancer risk (adjusted OR for highest versus lowest fourth: 0.91, 95% CI: 0.66-1.24, ptrend = 0.40) or UCC (n of cases = 776; 0.91, 0.65-1.26, ptrend = 0.40). There was no significant evidence of heterogeneity in the association of IGF-I with bladder cancer risk by tumour aggressiveness, sex, smoking status, or by time between blood collection and diagnosis (pheterogeneity > 0.05 for all). This first prospective study indicates no evidence of an association between plasma IGF-I concentrations and bladder cancer risk.
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000141418 7001_ $$aTravis, Ruth C$$b1
000141418 7001_ $$aAppleby, Paul N$$b2
000141418 7001_ $$aTipper, Sarah$$b3
000141418 7001_ $$aWeiderpass, Elisabete$$b4
000141418 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, Jenny$$b5$$udkfz
000141418 7001_ $$aGram, Inger T$$b6
000141418 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b7$$udkfz
000141418 7001_ $$aKiemeney, Lambertus A$$b8
000141418 7001_ $$aLjungberg, Börje$$b9
000141418 7001_ $$aTumino, Rosario$$b10
000141418 7001_ $$aTjønneland, Anne$$b11
000141418 7001_ $$00000-0003-3071-1658$$aRoswall, Nina$$b12
000141418 7001_ $$aOvervad, Kim$$b13
000141418 7001_ $$aBoutron-Ruault, Marie-Christine$$b14
000141418 7001_ $$aManciniveri, Francesca Romana$$b15
000141418 7001_ $$aSeveri, Gianluca$$b16
000141418 7001_ $$aTrichopoulou, Antonia$$b17
000141418 7001_ $$00000-0002-5758-9069$$aMasala, Giovanna$$b18
000141418 7001_ $$00000-0002-8008-5096$$aSacerdote, Carlotta$$b19
000141418 7001_ $$aAgnoli, Claudia$$b20
000141418 7001_ $$aPanico, Salvatore$$b21
000141418 7001_ $$aBueno-de-Mesquita, Bas$$b22
000141418 7001_ $$aPeeters, Petra H$$b23
000141418 7001_ $$aSalamanca-Fernández, Elena$$b24
000141418 7001_ $$aChirlaque, Maria-Dolores$$b25
000141418 7001_ $$aArdanaz, Eva$$b26
000141418 7001_ $$aDorronsoro, Miren$$b27
000141418 7001_ $$aMenéndez, Virginia$$b28
000141418 7001_ $$aLuján-Barroso, Leila$$b29
000141418 7001_ $$aLiedberg, Fredrik$$b30
000141418 7001_ $$aFreisling, Heinz$$b31
000141418 7001_ $$aGunter, Marc$$b32
000141418 7001_ $$aAune, Dagfinn$$b33
000141418 7001_ $$aCross, Amanda J$$b34
000141418 7001_ $$aRiboli, Elio$$b35
000141418 7001_ $$aKey, Timothy J$$b36
000141418 7001_ $$00000-0002-5652-356X$$aPerez-Cornago, Aurora$$b37
000141418 773__ $$0PERI:(DE-600)1474822-8$$a10.1002/ijc.31650$$gVol. 143, no. 10, p. 2351 - 2358$$n10$$p2351 - 2358$$tInternational journal of cancer$$v143$$x0020-7136$$y2018
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