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@ARTICLE{Lin:141418,
      author       = {C. Lin and R. C. Travis and P. N. Appleby and S. Tipper and
                      E. Weiderpass and J. Chang-Claude$^*$ and I. T. Gram and R.
                      Kaaks$^*$ and L. A. Kiemeney and B. Ljungberg and R. Tumino
                      and A. Tjønneland and N. Roswall and K. Overvad and M.-C.
                      Boutron-Ruault and F. R. Manciniveri and G. Severi and A.
                      Trichopoulou and G. Masala and C. Sacerdote and C. Agnoli
                      and S. Panico and B. Bueno-de-Mesquita and P. H. Peeters and
                      E. Salamanca-Fernández and M.-D. Chirlaque and E. Ardanaz
                      and M. Dorronsoro and V. Menéndez and L. Luján-Barroso and
                      F. Liedberg and H. Freisling and M. Gunter and D. Aune and
                      A. J. Cross and E. Riboli and T. J. Key and A.
                      Perez-Cornago},
      title        = {{P}re-diagnostic circulating insulin-like growth factor-{I}
                      and bladder cancer risk in the {E}uropean {P}rospective
                      {I}nvestigation into {C}ancer and {N}utrition.},
      journal      = {International journal of cancer},
      volume       = {143},
      number       = {10},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2018-01924},
      pages        = {2351 - 2358},
      year         = {2018},
      abstract     = {Previous in vitro and case-control studies have found an
                      association between the insulin-like growth factor
                      (IGF)-axis and bladder cancer risk. Circulating
                      concentrations of IGF-I have also been found to be
                      associated with an increased risk of several cancer types;
                      however, the relationship between pre-diagnostic circulating
                      IGF-I concentrations and bladder cancer has never been
                      studied prospectively. We investigated the association of
                      pre-diagnostic plasma concentrations of IGF-I with risk of
                      overall bladder cancer and urothelial cell carcinoma (UCC)
                      in a case-control study nested within the European
                      Prospective Investigation into Cancer and Nutrition (EPIC)
                      cohort. A total of 843 men and women diagnosed with bladder
                      cancer between 1992 and 2005 were matched with 843 controls
                      by recruitment centre, sex, age at recruitment, date of
                      blood collection, duration of follow-up, time of day and
                      fasting status at blood collection using an incidence
                      density sampling protocol. Odds ratios (ORs) and $95\%$
                      confidence intervals (CIs) were calculated using conditional
                      logistic regression with adjustment for smoking status. No
                      association was found between pre-diagnostic circulating
                      IGF-I concentration and overall bladder cancer risk
                      (adjusted OR for highest versus lowest fourth: 0.91, $95\%$
                      CI: 0.66-1.24, ptrend = 0.40) or UCC (n of cases = 776;
                      0.91, 0.65-1.26, ptrend = 0.40). There was no significant
                      evidence of heterogeneity in the association of IGF-I with
                      bladder cancer risk by tumour aggressiveness, sex, smoking
                      status, or by time between blood collection and diagnosis
                      (pheterogeneity > 0.05 for all). This first prospective
                      study indicates no evidence of an association between plasma
                      IGF-I concentrations and bladder cancer risk.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29971779},
      pmc          = {pmc:PMC6220964},
      doi          = {10.1002/ijc.31650},
      url          = {https://inrepo02.dkfz.de/record/141418},
}