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@ARTICLE{GonzalezGranda:141780,
      author       = {A. Gonzalez-Granda and A. Damms-Machado$^*$ and M. Basrai
                      and S. C. Bischoff},
      title        = {{C}hanges in {P}lasma {A}cylcarnitine and
                      {L}ysophosphatidylcholine {L}evels {F}ollowing a
                      {H}igh-{F}ructose {D}iet: {A} {T}argeted {M}etabolomics
                      {S}tudy in {H}ealthy {W}omen.},
      journal      = {Nutrients},
      volume       = {10},
      number       = {9},
      issn         = {2072-6643},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2018-02049},
      pages        = {1254},
      year         = {2018},
      abstract     = {The consumption of high amounts of fructose is associated
                      with metabolic diseases. However, the underlying mechanisms
                      are largely unknown.To determine the effects of high
                      fructose intake on plasma metabolomics.We enrolled 12
                      healthy volunteers (six lean and six obese women, age
                      24⁻35 years) in a crossover intervention study. All
                      participants carried out three diets: (1) low fructose (<10
                      g/day); (2) high fructose (100 g/day) from natural food
                      sources (fruit); and (3) high fructose (100 g/day) from high
                      fructose syrup (HFS).The primary outcome was changes in
                      plasma metabolites measured by targeted metabolomics.High
                      compared to low fructose diets caused a marked metabolite
                      class separation, especially because of changes in
                      acylcarnitine and lysophosphatidylcholine levels. Both high
                      fructose diets resulted in a decrease in mean acylcarnitine
                      levels in all subjects, and an increase in mean
                      lysophosphatidylcholine and diacyl-phosphatidylcholine
                      levels in obese individuals. Medium chain acylcarnitines
                      were negatively correlated with serum levels of liver
                      enzymes and with the fatty liver index.The metabolic shifts
                      induced by high fructose consumption suggest an inhibition
                      of mitochondrial β-oxidation and an increase in lipid
                      peroxidation. The effects tended to be more pronounced
                      following the HFS than the fruit diet.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30200659},
      pmc          = {pmc:PMC6165514},
      doi          = {10.3390/nu10091254},
      url          = {https://inrepo02.dkfz.de/record/141780},
}