000142083 001__ 142083
000142083 005__ 20240229105143.0
000142083 0247_ $$2doi$$a10.1158/0008-5472.CAN-18-0951
000142083 0247_ $$2pmid$$apmid:30054336
000142083 0247_ $$2pmc$$apmc:PMC6139053
000142083 0247_ $$2ISSN$$a0008-5472
000142083 0247_ $$2ISSN$$a0099-7013
000142083 0247_ $$2ISSN$$a0099-7374
000142083 0247_ $$2ISSN$$a1538-7445
000142083 0247_ $$2altmetric$$aaltmetric:45709202
000142083 037__ $$aDKFZ-2018-02313
000142083 041__ $$aeng
000142083 082__ $$a610
000142083 1001_ $$aLu, Yingchang$$b0
000142083 245__ $$aA Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk.
000142083 260__ $$aPhiladelphia, Pa.$$bAACR$$c2018
000142083 3367_ $$2DRIVER$$aarticle
000142083 3367_ $$2DataCite$$aOutput Types/Journal article
000142083 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1677746950_19617
000142083 3367_ $$2BibTeX$$aARTICLE
000142083 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000142083 3367_ $$00$$2EndNote$$aJournal Article
000142083 520__ $$aLarge-scale genome-wide association studies (GWAS) have identified approximately 35 loci associated with epithelial ovarian cancer (EOC) risk. The majority of GWAS-identified disease susceptibility variants are located in noncoding regions, and causal genes underlying these associations remain largely unknown. Here, we performed a transcriptome-wide association study to search for novel genetic loci and plausible causal genes at known GWAS loci. We used RNA sequencing data (68 normal ovarian tissue samples from 68 individuals and 6,124 cross-tissue samples from 369 individuals) and high-density genotyping data from European descendants of the Genotype-Tissue Expression (GTEx V6) project to build ovarian and cross-tissue models of genetically regulated expression using elastic net methods. We evaluated 17,121 genes for their cis-predicted gene expression in relation to EOC risk using summary statistics data from GWAS of 97,898 women, including 29,396 EOC cases. With a Bonferroni-corrected significance level of P < 2.2 × 10-6, we identified 35 genes, including FZD4 at 11q14.2 (Z = 5.08, P = 3.83 × 10-7, the cross-tissue model; 1 Mb away from any GWAS-identified EOC risk variant), a potential novel locus for EOC risk. All other 34 significantly associated genes were located within 1 Mb of known GWAS-identified loci, including 23 genes at 6 loci not previously linked to EOC risk. Upon conditioning on nearby known EOC GWAS-identified variants, the associations for 31 genes disappeared and three genes remained (P < 1.47 × 10-3). These data identify one novel locus (FZD4) and 34 genes at 13 known EOC risk loci associated with EOC risk, providing new insights into EOC carcinogenesis.Significance: Transcriptomic analysis of a large cohort confirms earlier GWAS loci and reveals FZD4 as a novel locus associated with EOC risk. Cancer Res; 78(18); 5419-30. ©2018 AACR.
000142083 536__ $$0G:(DE-HGF)POF3-319H$$a319H - Addenda (POF3-319H)$$cPOF3-319H$$fPOF III$$x0
000142083 588__ $$aDataset connected to CrossRef, PubMed,
000142083 7001_ $$aBeeghly-Fadiel, Alicia$$b1
000142083 7001_ $$aWu, Lang$$b2
000142083 7001_ $$aGuo, Xingyi$$b3
000142083 7001_ $$aLi, Bingshan$$b4
000142083 7001_ $$aSchildkraut, Joellen M$$b5
000142083 7001_ $$aIm, Hae Kyung$$b6
000142083 7001_ $$aChen, Yian A$$b7
000142083 7001_ $$00000-0002-4726-9264$$aPermuth, Jennifer B$$b8
000142083 7001_ $$aReid, Brett M$$b9
000142083 7001_ $$00000-0003-4513-0282$$aTeer, Jamie K$$b10
000142083 7001_ $$aMoysich, Kirsten B$$b11
000142083 7001_ $$aAndrulis, Irene L$$b12
000142083 7001_ $$aAnton-Culver, Hoda$$b13
000142083 7001_ $$aArun, Banu K$$b14
000142083 7001_ $$aBandera, Elisa V$$b15
000142083 7001_ $$aBarkardottir, Rosa B$$b16
000142083 7001_ $$00000-0002-3781-7570$$aBarnes, Daniel R$$b17
000142083 7001_ $$aBenitez, Javier$$b18
000142083 7001_ $$aBjorge, Line$$b19
000142083 7001_ $$aBrenton, James$$b20
000142083 7001_ $$aButzow, Ralf$$b21
000142083 7001_ $$00000-0002-1038-5392$$aCaldes, Trinidad$$b22
000142083 7001_ $$00000-0003-0589-1829$$aCaligo, Maria A$$b23
000142083 7001_ $$aCampbell, Ian$$b24
000142083 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, Jenny$$b25$$udkfz
000142083 7001_ $$aClaes, Kathleen B M$$b26
000142083 7001_ $$aCouch, Fergus J$$b27
000142083 7001_ $$aCramer, Daniel W$$b28
000142083 7001_ $$aDaly, Mary B$$b29
000142083 7001_ $$00000-0003-0057-4744$$adeFazio, Anna$$b30
000142083 7001_ $$00000-0003-4591-1214$$aDennis, Joe$$b31
000142083 7001_ $$aDiez, Orland$$b32
000142083 7001_ $$aDomchek, Susan M$$b33
000142083 7001_ $$aDörk, Thilo$$b34
000142083 7001_ $$aEaston, Douglas F$$b35
000142083 7001_ $$aEccles, Diana M$$b36
000142083 7001_ $$00000-0003-4885-8471$$aFasching, Peter A$$b37
000142083 7001_ $$0P:(DE-He78)74a6af8347ec5cbd4b77e562e10ca1f2$$aTurzanski-Fortner, Renée$$b38
000142083 7001_ $$aFountzilas, George$$b39
000142083 7001_ $$aFriedman, Eitan$$b40
000142083 7001_ $$aGanz, Patricia A$$b41
000142083 7001_ $$00000-0001-9449-3982$$aGarber, Judy$$b42
000142083 7001_ $$00000-0003-4946-9099$$aGiles, Graham G$$b43
000142083 7001_ $$aGodwin, Andrew K$$b44
000142083 7001_ $$aGoldgar, David E$$b45
000142083 7001_ $$aGoodman, Marc T$$b46
000142083 7001_ $$00000-0003-1852-9239$$aGreene, Mark H$$b47
000142083 7001_ $$aGronwald, Jacek$$b48
000142083 7001_ $$0P:(DE-He78)537e07b3e57b16c7b214fc2242e4326b$$aHamann, Ute$$b49
000142083 7001_ $$aHeitz, Florian$$b50
000142083 7001_ $$aHildebrandt, Michelle A T$$b51
000142083 7001_ $$aHøgdall, Claus K$$b52
000142083 7001_ $$aHollestelle, Antoinette$$b53
000142083 7001_ $$00000-0001-8397-4078$$aHulick, Peter J$$b54
000142083 7001_ $$aHuntsman, David G$$b55
000142083 7001_ $$aImyanitov, Evgeny N$$b56
000142083 7001_ $$00000-0002-9646-1260$$aIsaacs, Claudine$$b57
000142083 7001_ $$aJakubowska, Anna$$b58
000142083 7001_ $$00000-0002-4361-4657$$aJames, Paul$$b59
000142083 7001_ $$aKarlan, Beth Y$$b60
000142083 7001_ $$aKelemen, Linda E$$b61
000142083 7001_ $$00000-0002-2368-1326$$aKiemeney, Lambertus A$$b62
000142083 7001_ $$00000-0002-8347-1398$$aKjaer, Susanne K$$b63
000142083 7001_ $$aKwong, Ava$$b64
000142083 7001_ $$aLe, Nhu D$$b65
000142083 7001_ $$00000-0001-5756-6222$$aLeslie, Goska$$b66
000142083 7001_ $$00000-0001-7404-4549$$aLesueur, Fabienne$$b67
000142083 7001_ $$aLevine, Douglas A$$b68
000142083 7001_ $$aMattiello, Amalia$$b69
000142083 7001_ $$aMay, Taymaa$$b70
000142083 7001_ $$aMcGuffog, Lesley$$b71
000142083 7001_ $$00000-0002-9387-7586$$aMcNeish, Iain A$$b72
000142083 7001_ $$aMerritt, Melissa A$$b73
000142083 7001_ $$aModugno, Francesmary$$b74
000142083 7001_ $$aMontagna, Marco$$b75
000142083 7001_ $$aNeuhausen, Susan L$$b76
000142083 7001_ $$00000-0002-0916-2976$$aNevanlinna, Heli$$b77
000142083 7001_ $$aNielsen, Finn C$$b78
000142083 7001_ $$aNikitina-Zake, Liene$$b79
000142083 7001_ $$00000-0003-3445-8880$$aNussbaum, Robert L$$b80
000142083 7001_ $$aOffit, Kenneth$$b81
000142083 7001_ $$aOlah, Edith$$b82
000142083 7001_ $$aOlopade, Olufunmilayo I$$b83
000142083 7001_ $$aOlson, Sara H$$b84
000142083 7001_ $$aOlsson, Håkan$$b85
000142083 7001_ $$aOsorio, Ana$$b86
000142083 7001_ $$00000-0001-5002-9707$$aPark, Sue K$$b87
000142083 7001_ $$00000-0003-3242-8477$$aParsons, Michael T$$b88
000142083 7001_ $$aPeeters, Petra H M$$b89
000142083 7001_ $$aPejovic, Tanja$$b90
000142083 7001_ $$00000-0001-6951-6855$$aPeterlongo, Paolo$$b91
000142083 7001_ $$aPhelan, Catherine M$$b92
000142083 7001_ $$00000-0003-3222-4044$$aPujana, Miquel Angel$$b93
000142083 7001_ $$00000-0003-0005-7798$$aRamus, Susan J$$b94
000142083 7001_ $$00000-0002-8512-068X$$aRennert, Gad$$b95
000142083 7001_ $$aRisch, Harvey$$b96
000142083 7001_ $$aRodriguez, Gustavo C$$b97
000142083 7001_ $$00000-0001-8750-7338$$aRodríguez-Antona, Cristina$$b98
000142083 7001_ $$aRomieu, Isabelle$$b99
000142083 7001_ $$aRookus, Matti A$$b100
000142083 7001_ $$aRossing, Mary Anne$$b101
000142083 7001_ $$aRzepecka, Iwona K$$b102
000142083 7001_ $$00000-0002-6776-0018$$aSandler, Dale P$$b103
000142083 7001_ $$aSchmutzler, Rita K$$b104
000142083 7001_ $$aSetiawan, Veronica W$$b105
000142083 7001_ $$aSharma, Priyanka$$b106
000142083 7001_ $$aSieh, Weiva$$b107
000142083 7001_ $$aSimard, Jacques$$b108
000142083 7001_ $$aSinger, Christian F$$b109
000142083 7001_ $$aSong, Honglin$$b110
000142083 7001_ $$aSouthey, Melissa C$$b111
000142083 7001_ $$00000-0003-1337-7897$$aSpurdle, Amanda B$$b112
000142083 7001_ $$aSutphen, Rebecca$$b113
000142083 7001_ $$aSwerdlow, Anthony J$$b114
000142083 7001_ $$00000-0002-4896-5982$$aTeixeira, Manuel R$$b115
000142083 7001_ $$00000-0002-0444-590X$$aTeo, Soo H$$b116
000142083 7001_ $$aThomassen, Mads$$b117
000142083 7001_ $$aTischkowitz, Marc$$b118
000142083 7001_ $$aToland, Amanda E$$b119
000142083 7001_ $$aTrichopoulou, Antonia$$b120
000142083 7001_ $$aTung, Nadine$$b121
000142083 7001_ $$00000-0002-6986-7046$$aTworoger, Shelley S$$b122
000142083 7001_ $$00000-0003-2077-230X$$avan Rensburg, Elizabeth J$$b123
000142083 7001_ $$00000-0002-3984-2948$$aVanderstichele, Adriaan$$b124
000142083 7001_ $$aVega, Ana$$b125
000142083 7001_ $$aEdwards, Digna Velez$$b126
000142083 7001_ $$00000-0003-0733-5930$$aWebb, Penelope M$$b127
000142083 7001_ $$aWeitzel, Jeffrey N$$b128
000142083 7001_ $$aWentzensen, Nicolas$$b129
000142083 7001_ $$aWhite, Emily$$b130
000142083 7001_ $$00000-0001-7387-6845$$aWolk, Alicja$$b131
000142083 7001_ $$aWu, Anna H$$b132
000142083 7001_ $$aYannoukakos, Drakoulis$$b133
000142083 7001_ $$aZorn, Kristin K$$b134
000142083 7001_ $$aGayther, Simon A$$b135
000142083 7001_ $$aAntoniou, Antonis C$$b136
000142083 7001_ $$aBerchuck, Andrew$$b137
000142083 7001_ $$aGoode, Ellen L$$b138
000142083 7001_ $$aChenevix-Trench, Georgia$$b139
000142083 7001_ $$aSellers, Thomas A$$b140
000142083 7001_ $$aPharoah, Paul D P$$b141
000142083 7001_ $$aZheng, Wei$$b142
000142083 7001_ $$aLong, Jirong$$b143
000142083 773__ $$0PERI:(DE-600)2036785-5$$a10.1158/0008-5472.CAN-18-0951$$gVol. 78, no. 18, p. 5419 - 5430$$n18$$p5419 - 5430$$tCancer research$$v78$$x1538-7445$$y2018
000142083 909CO $$ooai:inrepo02.dkfz.de:142083$$pVDB
000142083 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aDeutsches Krebsforschungszentrum$$b25$$kDKFZ
000142083 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)74a6af8347ec5cbd4b77e562e10ca1f2$$aDeutsches Krebsforschungszentrum$$b38$$kDKFZ
000142083 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)537e07b3e57b16c7b214fc2242e4326b$$aDeutsches Krebsforschungszentrum$$b49$$kDKFZ
000142083 9131_ $$0G:(DE-HGF)POF3-319H$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vAddenda$$x0
000142083 9141_ $$y2018
000142083 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000142083 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000142083 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bCANCER RES : 2017
000142083 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000142083 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000142083 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000142083 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000142083 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000142083 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000142083 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000142083 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine
000142083 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000142083 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000142083 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bCANCER RES : 2017
000142083 9201_ $$0I:(DE-He78)C020-20160331$$kC020$$lC020 Epidemiologie von Krebs$$x0
000142083 9201_ $$0I:(DE-He78)B072-20160331$$kB072$$lMolekulargenetik des Mammakarzinoms$$x1
000142083 980__ $$ajournal
000142083 980__ $$aVDB
000142083 980__ $$aI:(DE-He78)C020-20160331
000142083 980__ $$aI:(DE-He78)B072-20160331
000142083 980__ $$aUNRESTRICTED