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| 001 | 142873 | ||
| 005 | 20240229112533.0 | ||
| 024 | 7 | _ | |a 10.1038/s41467-018-08054-4 |2 doi |
| 024 | 7 | _ | |a pmid:30683880 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC6347624 |2 pmc |
| 024 | 7 | _ | |a altmetric:54479532 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2019-00503 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 500 |
| 100 | 1 | _ | |a Jiang, Xia |b 0 |
| 245 | _ | _ | |a Shared heritability and functional enrichment across six solid cancers. |
| 260 | _ | _ | |a [London] |c 2019 |b Nature Publishing Group UK |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1677762459_19617 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10-8), breast and ovarian cancer (rg = 0.24, p = 7 × 10-5), breast and lung cancer (rg = 0.18, p =1.5 × 10-6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10-4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis. |
| 536 | _ | _ | |a 319H - Addenda (POF3-319H) |0 G:(DE-HGF)POF3-319H |c POF3-319H |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Neoplasm Proteins |2 NLM Chemicals |
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| 700 | 1 | _ | |a Schmit, Stephanie L |0 0000-0001-5931-1194 |b 3 |
| 700 | 1 | _ | |a Tyrer, Jonathan P |b 4 |
| 700 | 1 | _ | |a Han, Younghun |b 5 |
| 700 | 1 | _ | |a Michailidou, Kyriaki |0 0000-0001-7065-1237 |b 6 |
| 700 | 1 | _ | |a Lesseur, Corina |b 7 |
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