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@ARTICLE{Ferreira:143541,
author = {M. A. Ferreira and E. R. Gamazon and F. Al-Ejeh and K.
Aittomäki and I. L. Andrulis and H. Anton-Culver and A.
Arason and V. Arndt$^*$ and K. J. Aronson and B. K. Arun and
E. Asseryanis and J. Azzollini and J. Balmaña and D. R.
Barnes and D. Barrowdale and M. W. Beckmann and S.
Behrens$^*$ and J. Benitez and M. Bermisheva and K.
Białkowska and C. Blomqvist and N. V. Bogdanova and S. E.
Bojesen and M. K. Bolla and A. Borg and H. Brauch$^*$ and H.
Brenner$^*$ and A. Broeks and B. Burwinkel$^*$ and T.
Caldés and M. A. Caligo and D. Campa and I. Campbell and F.
Canzian$^*$ and J. Carter and B. D. Carter and J. E.
Castelao and J. Chang-Claude$^*$ and S. J. Chanock and H.
Christiansen and W. K. Chung and K. B. M. Claes and C. L.
Clarke and F. J. Couch and A. Cox and S. S. Cross and K.
Czene and M. B. Daly and M. de la Hoya and J. Dennis and P.
Devilee and O. Diez and T. Dörk and A. M. Dunning and M.
Dwek and D. M. Eccles and B. Ejlertsen and C. Ellberg and C.
Engel and M. Eriksson and P. A. Fasching and O. Fletcher and
H. Flyger and E. Friedman and D. Frost and M. Gabrielson and
M. Gago-Dominguez and P. A. Ganz and S. M. Gapstur and J.
Garber and M. García-Closas and J. A. García-Sáenz and M.
M. Gaudet and G. G. Giles and G. Glendon and A. K. Godwin
and M. S. Goldberg and D. E. Goldgar and A. González-Neira
and M. H. Greene and J. Gronwald and P. Guénel and C. A.
Haiman and P. Hall and U. Hamann$^*$ and W. He and J.
Heyworth and F. B. L. Hogervorst and A. Hollestelle and R.
N. Hoover and J. L. Hopper and P. J. Hulick and K. Humphreys
and E. N. Imyanitov and C. Isaacs and M. Jakimovska and A.
Jakubowska and P. A. James and R. Janavicius and R. C.
Jankowitz and E. M. John and N. Johnson and V. Joseph and B.
Y. Karlan and E. Khusnutdinova and J. I. Kiiski and Y.-D. Ko
and M. E. Jones and I. Konstantopoulou and V. N. Kristensen
and Y. Laitman and D. Lambrechts and C. Lazaro and G. Leslie
and J. Lester and F. Lesueur and S. Lindström and J. Long
and J. T. Loud and J. Lubiński and E. Makalic and A.
Mannermaa and M. Manoochehri and S. Margolin and T. Maurer
and D. Mavroudis and L. McGuffog and A. Meindl and U. Menon
and K. Michailidou and A. Miller and M. Montagna and F.
Moreno and L. Moserle and A. M. Mulligan and K. L. Nathanson
and S. L. Neuhausen and H. Nevanlinna and I. Nevelsteen and
F. C. Nielsen and L. Nikitina-Zake and R. L. Nussbaum and K.
Offit and E. Olah and O. I. Olopade and H. Olsson and A.
Osorio and J. Papp and T.-W. Park-Simon and M. T. Parsons
and I. S. Pedersen and A. Peixoto and P. Peterlongo and P.
D. P. Pharoah and D. Plaseska-Karanfilska and B. Poppe and
N. Presneau and P. Radice and J. Rantala and G. Rennert and
H. A. Risch and E. Saloustros and K. Sanden and E. J. Sawyer
and M. K. Schmidt and R. K. Schmutzler and P. Sharma and
X.-O. Shu and J. Simard and C. F. Singer and P. Soucy and M.
C. Southey and J. J. Spinelli and A. B. Spurdle and J. Stone
and A. J. Swerdlow and W. J. Tapper and J. A. Taylor and M.
R. Teixeira and M. B. Terry and A. Teulé and M. Thomassen
and K. Thöne and D. L. Thull and M. Tischkowitz and A. E.
Toland and D. Torres and T. Truong and N. Tung and C. M.
Vachon and C. J. van Asperen and A. M. W. van den Ouweland
and E. J. van Rensburg and A. Vega and A. Viel and Q. Wang
and B. Wappenschmidt and J. N. Weitzel and C. Wendt and R.
Winqvist and X. R. Yang and D. Yannoukakos and A. Ziogas and
P. Kraft and A. C. Antoniou and W. Zheng and D. F. Easton
and R. L. Milne and J. Beesley and G. Chenevix-Trench and J.
Adlard and M. Ahmed and J. Barwell and A. Brady and C.
Brewer and J. Cook and R. Davidson and A. Donaldson and J.
Eason and R. Eeles and D. G. Evans and H. Gregory and H.
Hanson and A. Henderson and S. Hodgson and L. Izatt and M.
J. Kennedy and F. Lalloo and C. Miller and P. J. Morrison
and K.-R. Ong and J. Perkins and M. E. Porteous and M. T.
Rogers and L. E. Side and K. Snape and L. Walker and P. A.
Harrington and N. Arnold and B. Auber and N.
Bogdanova-Markov and J. Borde and A. Caliebe and N. Ditsch
and B. Dworniczak and S. Engert and U. Faust and A. Gehrig
and E. Hahnen and J. Hauke and J. Hentschel and N. Herold
and E. Honisch and W. Just and K. Kast and M. Larsen and J.
Lemke and H. P. Nguyen and D. Niederacher and C.-E. Ott and
K. Platzer and E. Pohl-Rescigno and J. Ramser and K. Rhiem
and D. Steinemann and C. Sutter and R. Varon-Mateeva and S.
Wang-Gohrke and B. H. F. Weber and F. Prieur and P. Pujol
and C. Sagne and N. Sevenet and H. Sobol and J. Sokolowska
and D. Stoppa-Lyonnet and L. Venat-Bouvet and R. Balleine
and R. Baxter and S. Braye and J. Carpenter and J. Dahlstrom
and J. Forbes and S. C. Lee and D. Marsh and A. Morey and N.
Pathmanathan and P. Simpson and A. Spigelman and N. Wilcken
and D. Yip and B. A. M. Heemskerk-Gerritsen and M. A. Rookus
and C. M. Seynaeve and F. H. van der Baan and A. H. van der
Hout and L. E. van der Kolk and R. B. van der Luijt and C.
H. M. van Deurzen and H. C. van Doorn and K. van Engelen and
L. van Hest and T. A. M. van Os and S. Verhoef and M. J.
Vogel and J. T. Wijnen and A. Miron and M. Kapuscinski and
A. Bane and E. Ross and S. S. Buys and T. A. Conner},
collaboration = {EMBRACE Collaborators and GC-HBOC Study Collaborators and
GEMO Study Collaborators and A. Investigators and H.
Investigators and B. Investigators},
title = {{G}enome-wide association and transcriptome studies
identify target genes and risk loci for breast cancer.},
journal = {Nature Communications},
volume = {10},
number = {1},
issn = {2041-1723},
address = {[London]},
publisher = {Nature Publishing Group UK},
reportid = {DKFZ-2019-01124},
pages = {1741},
year = {2019},
abstract = {Genome-wide association studies (GWAS) have identified more
than 170 breast cancer susceptibility loci. Here we
hypothesize that some risk-associated variants might act in
non-breast tissues, specifically adipose tissue and immune
cells from blood and spleen. Using expression quantitative
trait loci (eQTL) reported in these tissues, we identify 26
previously unreported, likely target genes of overall breast
cancer risk variants, and 17 for estrogen receptor
(ER)-negative breast cancer, several with a known immune
function. We determine the directional effect of gene
expression on disease risk measured based on single and
multiple eQTL. In addition, using a gene-based test of
association that considers eQTL from multiple tissues, we
identify seven (and four) regions with variants associated
with overall (and ER-negative) breast cancer risk, which
were not reported in previous GWAS. Further investigation of
the function of the implicated genes in breast and immune
cells may provide insights into the etiology of breast
cancer.},
cin = {C071 / C070 / C020 / C080 / C055 / B072 / L101 / L801},
ddc = {500},
cid = {I:(DE-He78)C071-20160331 / I:(DE-He78)C070-20160331 /
I:(DE-He78)C020-20160331 / I:(DE-He78)C080-20160331 /
I:(DE-He78)C055-20160331 / I:(DE-He78)B072-20160331 /
I:(DE-He78)L101-20160331 / I:(DE-He78)L801-20160331},
pnm = {319H - Addenda (POF3-319H)},
pid = {G:(DE-HGF)POF3-319H},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:30988301},
pmc = {pmc:PMC6465407},
doi = {10.1038/s41467-018-08053-5},
url = {https://inrepo02.dkfz.de/record/143541},
}
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