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000147241 0247_ $$2doi$$a10.1093/ajcn/nqz222
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000147241 0247_ $$2ISSN$$a0002-9165
000147241 0247_ $$2ISSN$$a0095-9871
000147241 0247_ $$2ISSN$$a1938-3207
000147241 0247_ $$2ISSN$$a1938-3215
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000147241 037__ $$aDKFZ-2019-02367
000147241 041__ $$aeng
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000147241 1001_ $$aWedekind, Roland$$b0
000147241 245__ $$aSyringol metabolites as new biomarkers for smoked meat intake.
000147241 260__ $$aOxford$$bOxford University Press$$c2019
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000147241 500__ $$a 2019 Dec 1;110(6):1424-1433
000147241 520__ $$aProcessed meat intake is associated with a higher risk of colorectal and stomach cancers, coronary artery disease, and type 2 diabetes and with higher mortality, but the estimation of intake of different processed meat products in this heterogeneous food group in epidemiological studies remains challenging.This work aimed at identifying novel biomarkers for processed meat intake using metabolomics.An untargeted, multi-tiered metabolomics approach based on LC-MS was applied to 33 meat products digested in vitro and secondly to urine and plasma samples from a randomized crossover dietary intervention in which 12 volunteers consumed successively 3 processed meat products (bacon, salami, and hot dog) and 2 other foods used as controls, over 3 consecutive days. The putative biomarkers were then measured in urine from 474 subjects from the European Prospective Investigation into Cancer and Nutrition (EPIC) cross-sectional study for which detailed 24-h dietary recalls and FFQs were available.Syringol and 4 derivatives of syringol were found to be characteristic of in vitro digests of smoked meat products. The same compounds present as sulfate esters in urine increased at 2 and 12 h after consumption of smoked meat products (hot dog, bacon) in the intervention study. The same syringol sulfates were also positively associated with recent or habitual consumption of smoked meat products in urine samples from participants of the EPIC cross-sectional study. These compounds showed good discriminative ability for smoked meat intake with receiver operator characteristic areas under the curve ranging from 0.78 to 0.86 and 0.74 to 0.79 for short-term and habitual intake, respectively.Four novel syringol sulfates were identified as potential biomarkers of smoked meat intake and may be used to improve assessment of smoked meat intake in epidemiological studies. This trial was registered at clinicaltrials.gov as NCT03354130.
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000147241 7001_ $$aKeski-Rahkonen, Pekka$$b1
000147241 7001_ $$aRobinot, Nivonirina$$b2
000147241 7001_ $$aViallon, Vivian$$b3
000147241 7001_ $$aFerrari, Pietro$$b4
000147241 7001_ $$aEngel, Erwan$$b5
000147241 7001_ $$aBoutron-Ruault, Marie-Christine$$b6
000147241 7001_ $$aMahamat-Saleh, Yahya$$b7
000147241 7001_ $$aMancini, Francesca Romana$$b8
000147241 7001_ $$0P:(DE-He78)0907a10ba1dc8f53f04907f54f6fdcfe$$aKühn, Tilman$$b9$$udkfz
000147241 7001_ $$0P:(DE-He78)79ab945544e5bc017a2317b6146ed3aa$$aJohnson, Theron$$b10$$udkfz
000147241 7001_ $$aBoeing, Heiner$$b11
000147241 7001_ $$aBergmann, Manuela$$b12
000147241 7001_ $$aKarakatsani, Anna$$b13
000147241 7001_ $$aTrichopoulou, Antonia$$b14
000147241 7001_ $$aPeppa, Heleni$$b15
000147241 7001_ $$aAgnoli, Claudia$$b16
000147241 7001_ $$aSantucci de Magistris, Maria$$b17
000147241 7001_ $$aPalli, Domenico$$b18
000147241 7001_ $$aSacerdote, Carlotta$$b19
000147241 7001_ $$aTumino, Rosario$$b20
000147241 7001_ $$aGunter, Marc J$$b21
000147241 7001_ $$aHuybrechts, Inge$$b22
000147241 7001_ $$aScalbert, Augustin$$b23
000147241 773__ $$0PERI:(DE-600)1496439-9$$a10.1093/ajcn/nqz222$$gp. nqz222$$n6$$p1424-1433$$tThe American journal of clinical nutrition$$v110$$x1938-3207$$y2019
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