TY  - JOUR
AU  - Le Cornet, Charlotte
AU  - Walter, Britta
AU  - Sookthai, Disorn
AU  - Johnson, Theron S
AU  - Kühn, Tilman
AU  - Herpel, Ester
AU  - Kaaks, Rudolf
AU  - Turzanski-Fortner, Renée
TI  - Circulating 27-hydroxycholesterol and breast cancer tissue expression of CYP27A1, CYP7B1, LXR-β, and ERβ: results from the EPIC-Heidelberg cohort.
JO  - Breast cancer research
VL  - 22
IS  - 1
SN  - 1465-542X
CY  - London
PB  - BioMed Central
M1  - DKFZ-2020-00454
SP  - 23
PY  - 2020
N1  - #EA:C020#LA:C020#
AB  - Experimental and epidemiological studies demonstrate a role for 27-hydroxycholesterol (27HC) in breast cancer development, though results are conflicting. Cholesterol 27-hydroxylase (CYP27A1) and oxysterol 7-alpha-hydroxylase (CYP7B1) regulate 27HC concentrations, while differential expression of the liver X receptor (LXR) and estrogen receptor beta (ERβ) may impact the association between 27HC and breast cancer risk.We evaluated correlates of tumor tissue expression of CYP27A1, CYP7B1, LXR-β, and ERβ and the association between circulating prediagnostic 27HC concentrations and breast cancer risk by marker expression in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heidelberg cohort including 287 breast cancer cases with tumor tissue available. Tumor protein expression was evaluated using immunohistochemistry, and serum 27HC concentrations quantified using liquid chromatography-mass spectrometry. Conditional logistic regression models were used to estimate odds ratios (ORs) and 95
LB  - PUB:(DE-HGF)16
C6  - pmid:32075687
DO  - DOI:10.1186/s13058-020-1253-6
UR  - https://inrepo02.dkfz.de/record/153788
ER  -