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000154388 1001_ $$0P:(DE-He78)577a5c61f44b8023e229610afbc7cd4e$$aKorzowski, Andreas$$b0$$eFirst author$$udkfz
000154388 245__ $$aVolumetric mapping of intra- and extracellular pH in the human brain using 31 P MRSI at 7T.
000154388 260__ $$aNew York, NY [u.a.]$$bWiley-Liss$$c2020
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000154388 520__ $$aIn vivo 31 P MRSI enables noninvasive mapping of absolute pH values via the pH-dependent chemical shifts of inorganic phosphates (Pi ). A particular challenge is the quantification of extracellular Pi with low SNR in vivo. The purpose of this study was to demonstrate feasibility of assessing both intra- and extracellular pH across the whole human brain via volumetric 31 P MRSI at 7T.3D 31 P MRSI data sets of the brain were acquired from three healthy volunteers and three glioma patients. Low-rank denoising was applied to enhance the SNR of 31 P MRSI data sets that enables detection of extracellular Pi at high spatial resolutions. A robust two-compartment quantification model for intra- and extracellular Pi signals was implemented.In particular low-rank denoising enabled volumetric mapping of intra- and extracellular pH in the human brain with voxel sizes of 5.7 mL. The average intra- and extracellular pH measured in white matter of healthy volunteers were 7.00 ± 0.00 and 7.33 ± 0.03, respectively. In tumor tissue of glioma patients, both the average intra- and extracellular pH increased to 7.12 ± 0.01 and 7.44 ± 0.01, respectively, compared to normal appearing tissue.Mapping of pH values via 31 P MRSI at 7T using the proposed two-compartment quantification model improves reliability of pH values obtained in vivo, and has the potential to provide novel insights into the pH heterogeneity of various tissues.
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000154388 7001_ $$0P:(DE-He78)e9deaa758e8af7948e97a28aaf0bb7d1$$aWeinfurtner, Nina$$b1$$udkfz
000154388 7001_ $$00000-0003-2699-9214$$aMueller, Sebastian$$b2
000154388 7001_ $$0P:(DE-He78)8a54e49721e8ba58de289702bad026d9$$aBreitling, Johannes$$b3$$udkfz
000154388 7001_ $$00000-0002-0684-2423$$aGoerke, Steffen$$b4
000154388 7001_ $$0P:(DE-He78)3d04c8fee58c9ab71f62ff80d06b6fec$$aSchlemmer, Heinz-Peter$$b5$$udkfz
000154388 7001_ $$0P:(DE-He78)022611a2317e4de40fd912e0a72293a8$$aLadd, Mark E$$b6$$udkfz
000154388 7001_ $$0P:(DE-He78)c6e31fb8f19e185e254174554a0cccfc$$aPaech, Daniel$$b7$$udkfz
000154388 7001_ $$0P:(DE-He78)29b2f01310f7022916255ddba2750f9b$$aBachert, Peter$$b8$$eLast author$$udkfz
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