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| 001 | 154388 | ||
| 005 | 20240229123100.0 | ||
| 024 | 7 | _ | |a 10.1002/mrm.28255 |2 doi |
| 024 | 7 | _ | |a pmid:32237169 |2 pmid |
| 024 | 7 | _ | |a 0740-3194 |2 ISSN |
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| 037 | _ | _ | |a DKFZ-2020-00728 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Korzowski, Andreas |0 P:(DE-He78)577a5c61f44b8023e229610afbc7cd4e |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a Volumetric mapping of intra- and extracellular pH in the human brain using 31 P MRSI at 7T. |
| 260 | _ | _ | |a New York, NY [u.a.] |c 2020 |b Wiley-Liss |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1603190819_4948 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a e2020 Oct;84(4):1707-1723#EA:E020#LA:E020# |
| 520 | _ | _ | |a In vivo 31 P MRSI enables noninvasive mapping of absolute pH values via the pH-dependent chemical shifts of inorganic phosphates (Pi ). A particular challenge is the quantification of extracellular Pi with low SNR in vivo. The purpose of this study was to demonstrate feasibility of assessing both intra- and extracellular pH across the whole human brain via volumetric 31 P MRSI at 7T.3D 31 P MRSI data sets of the brain were acquired from three healthy volunteers and three glioma patients. Low-rank denoising was applied to enhance the SNR of 31 P MRSI data sets that enables detection of extracellular Pi at high spatial resolutions. A robust two-compartment quantification model for intra- and extracellular Pi signals was implemented.In particular low-rank denoising enabled volumetric mapping of intra- and extracellular pH in the human brain with voxel sizes of 5.7 mL. The average intra- and extracellular pH measured in white matter of healthy volunteers were 7.00 ± 0.00 and 7.33 ± 0.03, respectively. In tumor tissue of glioma patients, both the average intra- and extracellular pH increased to 7.12 ± 0.01 and 7.44 ± 0.01, respectively, compared to normal appearing tissue.Mapping of pH values via 31 P MRSI at 7T using the proposed two-compartment quantification model improves reliability of pH values obtained in vivo, and has the potential to provide novel insights into the pH heterogeneity of various tissues. |
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| 700 | 1 | _ | |a Weinfurtner, Nina |0 P:(DE-He78)e9deaa758e8af7948e97a28aaf0bb7d1 |b 1 |u dkfz |
| 700 | 1 | _ | |a Mueller, Sebastian |0 0000-0003-2699-9214 |b 2 |
| 700 | 1 | _ | |a Breitling, Johannes |0 P:(DE-He78)8a54e49721e8ba58de289702bad026d9 |b 3 |u dkfz |
| 700 | 1 | _ | |a Goerke, Steffen |0 0000-0002-0684-2423 |b 4 |
| 700 | 1 | _ | |a Schlemmer, Heinz-Peter |0 P:(DE-He78)3d04c8fee58c9ab71f62ff80d06b6fec |b 5 |u dkfz |
| 700 | 1 | _ | |a Ladd, Mark E |0 P:(DE-He78)022611a2317e4de40fd912e0a72293a8 |b 6 |u dkfz |
| 700 | 1 | _ | |a Paech, Daniel |0 P:(DE-He78)c6e31fb8f19e185e254174554a0cccfc |b 7 |u dkfz |
| 700 | 1 | _ | |a Bachert, Peter |0 P:(DE-He78)29b2f01310f7022916255ddba2750f9b |b 8 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1002/mrm.28255 |0 PERI:(DE-600)1493786-4 |n 4 |p 1707-1723 |t Magnetic resonance in medicine |v 84 |y 2020 |x 0740-3194 |
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