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000156832 1001_ $$0P:(DE-He78)0ad4af74a6b337e282ad0281595593bc$$aKratzer, Fabian$$b0$$eFirst author$$udkfz
000156832 245__ $$aSodium relaxometry using 23 Na MR fingerprinting: A proof of concept.
000156832 260__ $$aNew York, NY [u.a.]$$bWiley-Liss$$c2020
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000156832 500__ $$a2020 Nov;84(5):2577-2591#EA:E020#LA:E020#
000156832 520__ $$aTo evaluate the feasibility of 23 Na MR fingerprinting (MRF) for simultaneous quantification of T1 ,                                                       T                                                                                                   2                                     l                                                                                           ∗                                               ,                                                       T                                                                                                   2                                     s                                                                                           ∗                                               ,                                                       T                             2                             ∗                                               in addition to ΔB0 .A framework for sodium relaxometry using MRF at 7T was developed, allowing simultaneous measurement of relaxation times and inhomogeneities in the static field. The technique distinguishes between bi- and monoexponential transverse relaxation and was validated in simulations with respect to the ground truth. In phantom measurements, a resolution of 2 × 2 × 12 mm3 was achieved within 1 h acquisition time, and the resulting parameter maps were compared to results from reference methods. Relaxation times in five healthy volunteers were measured with a resolution of 4 × 4 × 12 mm3 .Phantom experiments revealed an agreement between the relaxation times obtained via 23 Na-MRF and the reference methods. In white matter, a longitudinal relaxation constant of T1 = 38.9 ± 4.8 ms was found, while values of                                                       T                                                                                                   2                                     l                                                                                           ∗                                               = 29.2 ± 4.9 ms and                                                       T                                                                                                   2                                     s                                                                                           ∗                                               = 4.7 ± 1.2 ms were found for the long and short component of the transverse relaxation. In cerebrospinal fluid, T1 was 67.7 ± 6.3 ms and                                                       T                             2                             ∗                                               = 41.5 ± 3.4 ms.This work demonstrates the feasibility of 23 Na-MRF for relaxometry in sodium MRI in both phantom and in vivo studies. Simultaneous quantification of T1 ,                                                       T                                                                                                   2                                     l                                                                                           ∗                                               ,                                                       T                                                                                                   2                                     s                                                                                           ∗                                               ,                                                       T                             2                             ∗                                               and ΔB0 was possible within a 1 h measurement time.
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000156832 7001_ $$0P:(DE-He78)6f29c4a184536f50b8629af3480c5932$$aFlassbeck, Sebastian$$b1$$udkfz
000156832 7001_ $$0P:(DE-He78)054fd7a5195b75b11fbdc5c360276011$$aNagel, Armin M$$b2$$udkfz
000156832 7001_ $$0P:(DE-He78)596c7f2f2a07a37019b79f94ad8a4190$$aBehl, Nicolas$$b3
000156832 7001_ $$0P:(DE-He78)2a87a11b02b8b69a8607d707f436330a$$aKnowles, Benjamin R$$b4$$udkfz
000156832 7001_ $$0P:(DE-He78)29b2f01310f7022916255ddba2750f9b$$aBachert, Peter$$b5$$udkfz
000156832 7001_ $$0P:(DE-He78)022611a2317e4de40fd912e0a72293a8$$aLadd, Mark E$$b6$$udkfz
000156832 7001_ $$0P:(DE-He78)19e2d877276b0e5eec11cdfc1789a55e$$aSchmitter, Sebastian$$b7$$eLast author$$udkfz
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