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000180172 1001_ $$0P:(DE-He78)6e02c183f41e45a5867dec393fb4616a$$aAmitay, Efrat$$b0$$eFirst author$$udkfz
000180172 245__ $$aReproductive factors and colorectal cancer risk: A Population-based case-control study.
000180172 260__ $$aOxford$$bOxford University Press$$c2022
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000180172 500__ $$a#EA:C070#LA:C070#LA:C120# / 2022 Jul 1;6(4):pkac042
000180172 520__ $$aHormone-replacement therapy (HRT) is associated with lower colorectal cancer (CRC) risk among postmenopausal women. However, little is known about effects of lifetime exposure of women to varying levels of estrogen and progesterone through reproductive factors such as parity, use of oral contraceptives (OC), breastfeeding and menstruation on CRC risk.We assessed associations between reproductive factors and CRC risk among 2650 female CRC patients aged 30+ years and 2175 matched controls in a population-based study in Germany, adjusting for potential confounders by multiple logistic regression.Inverse associations with CRC risk were found for numbers of pregnancies (OR per pregnancy=0.91, 95%CI 0.86-0.97), breastfeeding for ≥12 months (OR = 0.74, 95%CI 0.61-0.90), use of either OC or HRT (OR = 0.75, 95%CI 0.64-0.87) or both (OR = 0.58, 95%CI 0.48-0.70). Similar results were found for postmenopausal women only and when adjusting for number of pregnancies and for all reproductive factors analyzed together. Breastfeeding duration of ≥ 12 months was associated with lower risk of cancer only in the proximal colon (OR = 0.58, 95%CI 0.45-0.74).Several reproductive factors were associated with lower CRC risk in women, including number of pregnancies, breastfeeding duration and use of OC and HRT. This suggests that women's exposure to female reproductive hormones play a key role in the difference in CRC risk between women and men and in site-specific CRC risk.
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000180172 650_7 $$2Other$$abreastfeeding
000180172 650_7 $$2Other$$acolorectal cancer
000180172 650_7 $$2Other$$aoral contraceptives
000180172 650_7 $$2Other$$apregnancy
000180172 650_7 $$2Other$$areproductive factors
000180172 650_7 $$2Other$$awomen
000180172 7001_ $$0P:(DE-He78)20dc4ad11ff465acf5b99f1e679e10b7$$aNiedermaier, Tobias$$b1$$udkfz
000180172 7001_ $$0P:(DE-He78)9b2a61b2abe4a64ca23b6783b7c4fe63$$aAlwers, Elizabeth$$b2$$udkfz
000180172 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, Jenny$$b3$$udkfz
000180172 7001_ $$0P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f$$aHoffmeister, Michael$$b4$$udkfz
000180172 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b5$$eLast author$$udkfz
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