AU  - Martos-Folgado, Inmaculada
AU  - Del Monte-Monge, Alberto
AU  - Lorenzo, Cristina
AU  - Busse, Christian E
AU  - Delgado, Pilar
AU  - Mur, Sonia M
AU  - Cobos-Figueroa, Laura
AU  - Escolà-Gil, Joan C
AU  - Martín-Ventura, Jose L
AU  - Wardemann, Hedda
AU  - Ramiro, Almudena R
TI  - MDA-LDL vaccination induces athero-protective germinal-center-derived antibody responses.
JO  - Cell reports
VL  - 41
IS  - 2
SN  - 2211-1247
CY  - [New York, NY]
PB  - Elsevier
M1  - DKFZ-2022-02389
SP  - 111468
PY  - 2022
AB  - Atherosclerosis is a chronic inflammatory disease of the arteries that can lead to thrombosis, infarction, and stroke and is the leading cause of mortality worldwide. Immunization of pro-atherogenic mice with malondialdehyde-modified low-density lipoprotein (MDA-LDL) neo-antigen is athero-protective. However, the immune response to MDA-LDL and the mechanisms responsible for this athero-protection are not completely understood. Here, we find that immunization of mice with MDA-LDL elicits memory B cells, plasma cells, and switched anti-MDA-LDL antibodies as well as clonal expansion and affinity maturation, indicating that MDA-LDL triggers a bona fide germinal center antibody response. Further, Prdm1fl/flAicda-Cre+/kiLdlr-/- pro-atherogenic chimeras, which lack germinal center-derived plasma cells, show accelerated atherosclerosis. Finally, we show that MDA-LDL immunization is not athero-protective in mice lacking germinal-center-derived plasma cells. Our findings give further support to the development of MDA-LDL-based vaccines for the prevention or treatment of atherosclerosis.
KW  - B cell (Other)
KW  - CP: Immunology (Other)
KW  - MDA-LDL (Other)
KW  - antibody (Other)
KW  - atherosclerosis (Other)
KW  - germinal center (Other)
KW  - vaccine (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36223741
DO  - DOI:10.1016/j.celrep.2022.111468
UR  - https://inrepo02.dkfz.de/record/182061
ER  -