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      author       = {C. Hutton and F. Heider and A. Blanco-Gomez and A. Banyard
                      and A. Kononov and X. Zhang and S. Karim and V. Paulus-Hock
                      and D. Watt and N. Steele and S. Kemp and E. K. J. Hogg and
                      J. Kelly and R.-F. Jackstadt and F. Lopes and M. Menotti and
                      L. Chisholm and A. Lamarca and J. Valle and O. J. Sansom and
                      C. Springer and A. Malliri and R. Marais and M. Pasca di
                      Magliano and S. Zelenay and J. P. Morton and C. Jørgensen},
      title        = {{S}ingle-cell analysis defines a pancreatic fibroblast
                      lineage that supports anti-tumor immunity},
      journal      = {Cancer cell},
      volume       = {39},
      number       = {9},
      issn         = {1535-6108},
      address      = {New York, NY},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2022-03106},
      pages        = {1227 - 1244.e20},
      year         = {2021},
      abstract     = {Fibroblasts display extensive transcriptional
                      heterogeneity, yet functional annotation and
                      characterization of their heterocellular relationships
                      remains incomplete. Using mass cytometry, we chart the
                      stromal composition of 18 murine tissues and 5 spontaneous
                      tumor models, with an emphasis on mesenchymal phenotypes.
                      This analysis reveals extensive stromal heterogeneity across
                      tissues and tumors, and identifies coordinated relationships
                      between mesenchymal and immune cell subsets in pancreatic
                      ductal adenocarcinoma. Expression of CD105 demarks two
                      stable and functionally distinct pancreatic fibroblast
                      lineages, which are also identified in murine and human
                      healthy tissues and tumors. Whereas CD105-positive
                      pancreatic fibroblasts are permissive for tumor growth in
                      vivo, CD105-negative fibroblasts are highly tumor
                      suppressive. This restrictive effect is entirely dependent
                      on functional adaptive immunity. Collectively, these results
                      reveal two functionally distinct pancreatic fibroblast
                      lineages and highlight the importance of mesenchymal and
                      immune cell interactions in restricting tumor growth.},
      ddc          = {610},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1016/j.ccell.2021.06.017},
      url          = {https://inrepo02.dkfz.de/record/186338},