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000186686 1001_ $$aCasalone, Elisabetta$$b0
000186686 245__ $$aSerum Extracellular Vesicle-Derived microRNAs as Potential Biomarkers for Pleural Mesothelioma in a European Prospective Study.
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000186686 520__ $$aMalignant pleural mesothelioma (MPM) is an aggressive cancer with a dismal prognosis. Early therapeutic interventions could improve patient outcomes. We aimed to identify a pattern of microRNAs (miRNAs) as potential early non-invasive markers of MPM. In a case-control study nested in the European Prospective Investigation into Cancer and Nutrition cohort, we screened the whole miRNome in serum extracellular vesicles (EVs) of preclinical MPM cases. In a subgroup of 20 preclinical samples collected five years prior MPM diagnosis, we observed an upregulation of miR-11400 (fold change (FC) = 2.6, adjusted p-value = 0.01), miR-148a-3p (FC = 1.5, p-value = 0.001), and miR-409-3p (FC = 1.5, p-value = 0.04) relative to matched controls. The 3-miRNA panel showed a good classification capacity with an area under the receiver operating characteristic curve (AUC) of 0.81 (specificity = 0.75, sensitivity = 0.70). The diagnostic ability of the model was also evaluated in an independent retrospective cohort, yielding a higher predictive power (AUC = 0.86). A signature of EV miRNA can be detected up to five years before MPM; moreover, the identified miRNAs could provide functional insights into the molecular changes related to the late carcinogenic process, preceding MPM development.
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000186686 650_7 $$2Other$$abiomarkers
000186686 650_7 $$2Other$$aearly changes
000186686 650_7 $$2Other$$amalignant pleural mesothelioma
000186686 650_7 $$2Other$$amicroRNAs
000186686 650_7 $$2Other$$anext generation sequencing
000186686 7001_ $$00000-0003-0160-9312$$aBirolo, Giovanni$$b1
000186686 7001_ $$00000-0001-9571-4257$$aPardini, Barbara$$b2
000186686 7001_ $$aAllione, Alessandra$$b3
000186686 7001_ $$00000-0002-5494-2218$$aRusso, Alessia$$b4
000186686 7001_ $$aCatalano, Chiara$$b5
000186686 7001_ $$aMencoboni, Manlio$$b6
000186686 7001_ $$00000-0003-4929-3759$$aFerrante, Daniela$$b7
000186686 7001_ $$00000-0001-6413-5471$$aMagnani, Corrado$$b8
000186686 7001_ $$aSculco, Marika$$b9
000186686 7001_ $$aDianzani, Irma$$b10
000186686 7001_ $$aGrosso, Federica$$b11
000186686 7001_ $$aMirabelli, Dario$$b12
000186686 7001_ $$aFiliberti, Rosa Angela$$b13
000186686 7001_ $$aRena, Ottavio$$b14
000186686 7001_ $$00000-0002-8008-5096$$aSacerdote, Carlotta$$b15
000186686 7001_ $$00000-0002-9972-9779$$aRodriguez-Barranco, Miguel$$b16
000186686 7001_ $$aSmith-Byrne, Karl$$b17
000186686 7001_ $$aPanico, Salvatore$$b18
000186686 7001_ $$aAgnoli, Claudia$$b19
000186686 7001_ $$0P:(DE-He78)79ab945544e5bc017a2317b6146ed3aa$$aJohnson, Theron$$b20$$udkfz
000186686 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b21$$udkfz
000186686 7001_ $$aTumino, Rosario$$b22
000186686 7001_ $$aHuerta, José María$$b23
000186686 7001_ $$aRiboli, Elio$$b24
000186686 7001_ $$00000-0001-6517-1300$$aHeath, Alicia K$$b25
000186686 7001_ $$00000-0001-5105-252X$$aTrobajo-Sanmartín, Camino$$b26
000186686 7001_ $$00000-0002-0830-5277$$aSchulze, Matthias B$$b27
000186686 7001_ $$00000-0002-0117-1608$$aSaieva, Calogero$$b28
000186686 7001_ $$aAmiano, Pilar$$b29
000186686 7001_ $$aAgudo, Antonio$$b30
000186686 7001_ $$00000-0003-2237-0128$$aWeiderpass, Elisabete$$b31
000186686 7001_ $$aVineis, Paolo$$b32
000186686 7001_ $$00000-0003-0674-7757$$aMatullo, Giuseppe$$b33
000186686 773__ $$0PERI:(DE-600)2527080-1$$a10.3390/cancers15010125$$gVol. 15, no. 1, p. 125 -$$n1$$p125$$tCancers$$v15$$x2072-6694$$y2023
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