TY  - JOUR
AU  - Chapman, Rebecca J
AU  - Ghasemi, David R
AU  - Andreiuolo, Felipe
AU  - Zschernack, Valentina
AU  - Tauziede Espariat, Arnault
AU  - Buttarelli, Francesca R
AU  - Giangaspero, Felice
AU  - Grill, Jacques
AU  - Haberler, Christine
AU  - Paine, Simon M L
AU  - Scott, Ian
AU  - Jacques, Thomas S
AU  - Sill, Martin
AU  - Pfister, Stefan
AU  - Kilday, John-Paul
AU  - Leblond, Pierre
AU  - Massimino, Maura
AU  - Witt, Hendrik
AU  - Modena, Piergiorgio
AU  - Varlet, Pascale
AU  - Pietsch, Torsten
AU  - Grundy, Richard G
AU  - Pajtler, Kristian
AU  - Ritzmann, Timothy A
AU  - Childhood, Biomarkers of Ependymoma in
TI  - Optimising biomarkers for accurate ependymoma diagnosis, prognostication and stratification within International Clinical Trials: A BIOMECA study.
JO  - Neuro-Oncology
VL  - 25
IS  - 10
SN  - 1522-8517
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DKFZ-2023-00529
SP  - 1871-1882
PY  - 2023
N1  - #LA:B062# / 2023 Oct 3;25(10):1871-1882
AB  - Accurate identification of brain tumour molecular subgroups is increasingly important. We aimed to establish the most accurate and reproducible ependymoma subgroup biomarker detection techniques, across 147 cases from International Society of Pediatric Oncology (SIOP) Ependymoma II trial participants, enrolled in the pan-European 'Biomarkers of Ependymoma in Children and Adolescents (BIOMECA)' study.Across six European BIOMECA laboratories we evaluated epigenetic profiling (DNA methylation array); immunohistochemistry (IHC) for nuclear p65-RELA, H3K27me3, and Tenascin-C; copy number analysis via FISH and MLPA (1q, CDKN2A), and MIP and DNA methylation array (genome-wide copy number evaluation); analysis of ZFTA- and YAP1-fusions by RT-PCR and sequencing, Nanostring and break-apart FISH.DNA Methylation profiling classified 65.3
KW  - Ependymoma (Other)
KW  - biomarkers (Other)
KW  - brain tumours (Other)
KW  - neuro-oncology (Other)
KW  - paediatric (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36916248
DO  - DOI:10.1093/neuonc/noad055
UR  - https://inrepo02.dkfz.de/record/274243
ER  -