TY  - JOUR
AU  - Regnery, Sebastian
AU  - Katsigiannopulos, Efthimios
AU  - Hoegen, Philipp
AU  - Weykamp, Fabian
AU  - Sandrini, Elisabetta
AU  - Held, Thomas
AU  - Deng, Maximilian
AU  - Eichkorn, Tanja
AU  - Buchele, Carolin
AU  - Rippke, Carolin
AU  - Renkamp, C Katharina
AU  - König, Laila
AU  - Lang, Kristin
AU  - Thomas, Michael
AU  - Winter, Hauke
AU  - Adeberg, Sebastian
AU  - Klüter, Sebastian
AU  - Debus, Jürgen
AU  - Hörner-Rieber, Juliane
TI  - To fly or not to fly: Stereotactic MR-guided adaptive radiotherapy effectively treats ultracentral lung tumors with favorable long-term outcomes.
JO  - Lung cancer
VL  - 179
SN  - 0169-5002
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DKFZ-2023-00606
SP  - 107175
PY  - 2023
N1  - #LA:E050#
AB  - Stereotactic radiotherapy of ultracentral lung tumors (ULT) is challenging as it may cause overdoses to sensitive mediastinal organs with severe complications. We aimed to describe long-term outcomes after stereotactic magnetic resonance (MR)-guided online adaptive radiotherapy (SMART) as an innovative treatment of ULT.We analyzed 36 patients that received SMART to 40 tumors between 02/2020 - 08/2021 inside prospective databases. ULT were defined by planning target volume (PTV) overlap with the proximal bronchial tree or esophagus. We calculated Kaplan Meier estimates for overall survival (OS) and progression-free survival (PFS), and competing risk estimates for the incidence of tumor progression and treatment-related toxicities. ULT patients (N = 16) were compared to non-ULT patients (N = 20).Baseline characteristics were similar between ULT and non-ULT, but ULT were larger (median PTV: ULT 54.7 cm3, non-ULT 19.2 cm3). Median follow-up was 23.6 months. ULT and non-ULT showed a similar OS (2-years: ULT 67
KW  - Image-guided radiotherapy (IGRT) (Other)
KW  - MR-guided adaptive radiotherapy (Other)
KW  - Magnetic resonance imaging (MRI) (Other)
KW  - Pulmonary cancer (Other)
KW  - Stereotactic body radiotherapy (SABR) (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36965207
DO  - DOI:10.1016/j.lungcan.2023.03.011
UR  - https://inrepo02.dkfz.de/record/274461
ER  -