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@ARTICLE{Onyshchenko:275373,
      author       = {K. Onyshchenko$^*$ and R. Luo$^*$ and E. Guffart and S.
                      Gaedicke and A.-L. Grosu$^*$ and E. Firat and G.
                      Niedermann$^*$},
      title        = {{E}xpansion of circulating stem-like {CD}8+ {T} cells by
                      adding {CD}122-directed {IL}-2 complexes to radiation and
                      anti-{PD}1 therapies in mice.},
      journal      = {Nature Communications},
      volume       = {14},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2023-00739},
      pages        = {2087},
      year         = {2023},
      abstract     = {Combination of radiation therapy (RT) with immune
                      checkpoint blockade can enhance systemic anti-tumor T cell
                      responses. Here, using two mouse tumor models, we
                      demonstrate that adding long-acting CD122-directed IL-2
                      complexes (IL-2c) to RT/anti-PD1 further increases
                      tumor-specific CD8+ T cell numbers. The highest increase
                      (>50-fold) is found in the blood circulation. Compartmental
                      analysis of exhausted T cell subsets shows that primarily
                      undifferentiated, stem-like, tumor-specific CD8+ T cells
                      expand in the blood; these cells express the chemokine
                      receptor CXCR3, which is required for migration into tumors.
                      In tumor tissue, effector-like but not terminally
                      differentiated exhausted CD8+ T cells increase. Consistent
                      with the surge in tumor-specific CD8+ T cells in blood that
                      are migration and proliferation competent, we observe a
                      CD8-dependent and CXCR3-dependent enhancement of the
                      abscopal effect against distant/non-irradiated tumors and
                      find that CD8+ T cells isolated from blood after
                      RT/anti-PD1/IL-2c triple treatment can be a rich source of
                      tumor-specific T cells for adoptive transfers.},
      cin          = {FR01},
      ddc          = {500},
      cid          = {I:(DE-He78)FR01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37045833},
      doi          = {10.1038/s41467-023-37825-x},
      url          = {https://inrepo02.dkfz.de/record/275373},
}