TY  - JOUR
AU  - Corradi, Chiara
AU  - Lencioni, Giulia
AU  - Gentiluomo, Manuel
AU  - Felici, Alessio
AU  - Latiano, Anna
AU  - Kiudelis, Gediminas
AU  - van Eijck, Casper H J
AU  - Marta, Katalin
AU  - Lawlor, Rita T
AU  - Tavano, Francesca
AU  - Boggi, Ugo
AU  - Dijk, Frederike
AU  - Cavestro, Giulia Martina
AU  - Vermeulen, Roel C H
AU  - Hackert, Thilo
AU  - Petrone, Maria Chiara
AU  - Uzunoğlu, Faik Güntac
AU  - Archibugi, Livia
AU  - Izbicki, Jakob R
AU  - Morelli, Luca
AU  - Zerbi, Alessandro
AU  - Landi, Stefano
AU  - Stocker, Hannah
AU  - Talar-Wojnarowska, Renata
AU  - Di Franco, Gregorio
AU  - Hegyi, Péter
AU  - Sperti, Cosimo
AU  - Carrara, Silvia
AU  - Capurso, Gabriele
AU  - Gazouli, Maria
AU  - Brenner, Hermann
AU  - Bunduc, Stefania
AU  - Busch, Olivier
AU  - Perri, Francesco
AU  - Oliverius, Martin
AU  - Hegyi, Péter Jeno
AU  - Goetz, Mara
AU  - Scognamiglio, Pasquale
AU  - Mambrini, Andrea
AU  - Arcidiacono, Paolo Giorgio
AU  - Kreivenaite, Edita
AU  - Kupcinskas, Juozas
AU  - Hussein, Tamas
AU  - Ermini, Stefano
AU  - Milanetto, Anna Caterina
AU  - Vodicka, Pavel
AU  - Kiudelis, Vytautas
AU  - Hlaváč, Viktor
AU  - Soucek, Pavel
AU  - Theodoropoulos, George E
AU  - Basso, Daniela
AU  - Neoptolemos, John P
AU  - Nóbrega Aoki, Mateus
AU  - Pezzilli, Raffaele
AU  - Pasquali, Claudio
AU  - Chammas, Roger
AU  - Testoni, Sabrina Gloria Giulia
AU  - Mohelnikova-Duchonova, Beatrice
AU  - Lucchesi, Maurizio
AU  - Rizzato, Cosmeri
AU  - Canzian, Federico
AU  - Campa, Daniele
TI  - Polymorphic variants involved in methylation regulation: a strategy to discover risk loci for pancreatic ductal adenocarcinoma.
JO  - Journal of medical genetics
VL  - 60
IS  - 10
SN  - 0022-2593
CY  - London
PB  - BMJ Publishing Group
M1  - DKFZ-2023-00871
SP  - 980-986
PY  - 2023
N1  - 2023 Oct;60(10):980-986
AB  - Only a small number of risk factors for pancreatic ductal adenocarcinoma (PDAC) has been established. Several studies identified a role of epigenetics and of deregulation of DNA methylation. DNA methylation is variable across a lifetime and in different tissues; nevertheless, its levels can be regulated by genetic variants like methylation quantitative trait loci (mQTLs), which can be used as a surrogate.We scanned the whole genome for mQTLs and performed an association study in 14 705 PDAC cases and 246 921 controls. The methylation data were obtained from whole blood and pancreatic cancer tissue through online databases. We used the Pancreatic Cancer Cohort Consortium and the Pancreatic Cancer Case-Control Consortium genome-wide association study (GWAS) data as discovery phase and the Pancreatic Disease Research consortium, the FinnGen project and the Japan Pancreatic Cancer Research consortium GWAS as replication phase.The C allele of 15q26.1-rs12905855 showed an association with a decreased risk of PDAC (OR=0.90, 95
KW  - DNA Methylation (Other)
KW  - Genetic Variation (Other)
KW  - Genetics (Other)
KW  - Germ-Line Mutation (Other)
KW  - Molecular Epidemiology (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37130759
DO  - DOI:10.1136/jmg-2022-108910
UR  - https://inrepo02.dkfz.de/record/275777
ER  -