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@ARTICLE{Namgaladze:275938,
      author       = {D. Namgaladze and B. Brüne$^*$},
      title        = {{R}apid glycolytic activation accompanying innate immune
                      responses: mechanisms and function.},
      journal      = {Frontiers in immunology},
      volume       = {14},
      issn         = {1664-3224},
      address      = {Lausanne},
      publisher    = {Frontiers Media},
      reportid     = {DKFZ-2023-00926},
      pages        = {1180488},
      year         = {2023},
      abstract     = {Innate immune responses to pathogens, mediated by
                      activation of pattern recognition receptors and downstream
                      signal transduction cascades, trigger rapid transcriptional
                      and epigenetic changes to support increased expression of
                      pro-inflammatory cytokines and other effector molecules.
                      Innate immune cells also rapidly rewire their metabolism.
                      The most prominent metabolic alteration following innate
                      immune activation is rapid up-regulation of glycolysis. In
                      this mini-review, we summarize recent advances regarding the
                      mechanisms of rapid glycolytic activation in innate immune
                      cells, highlighting the relevant signaling components. We
                      also discuss the impact of glycolytic activation on
                      inflammatory responses, including the recently elucidated
                      links of metabolism and epigenetics. Finally, we highlight
                      unresolved mechanistic details of glycolytic activation and
                      possible avenues of future research in this area.},
      subtyp        = {Review Article},
      keywords     = {Immunity, Innate / Signal Transduction / Receptors, Pattern
                      Recognition: metabolism / Cytokines: metabolism / Glycolysis
                      / dendritic cell (Other) / glycolysis (Other) / inflammation
                      (Other) / macrophage (Other) / metabolism (Other) / pattern
                      recognition receptors (Other) / Receptors, Pattern
                      Recognition (NLM Chemicals) / Cytokines (NLM Chemicals)},
      cin          = {FM01},
      ddc          = {610},
      cid          = {I:(DE-He78)FM01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37153593},
      pmc          = {pmc:PMC10158531},
      doi          = {10.3389/fimmu.2023.1180488},
      url          = {https://inrepo02.dkfz.de/record/275938},
}