TY  - JOUR
AU  - Kersting, Josephine
AU  - Ranft, Andreas
AU  - Bhadri, Vivek
AU  - Brichard, Bénédicte
AU  - Collaud, Stéphane
AU  - Cyprová, Sona
AU  - Eich, Hans
AU  - Ek, Torben
AU  - Gelderblom, Hans
AU  - Hardes, Jendrik
AU  - Haveman, Lianne
AU  - Hartmann, Wolfgang
AU  - Hauser, Peter
AU  - Heesen, Philip
AU  - Jürgens, Heribert
AU  - Kanerva, Jukka
AU  - Kühne, Thomas
AU  - Raciborska, Anna
AU  - Rascon, Jelena
AU  - Rechl, Victor
AU  - Streitbürger, Arne
AU  - Timmermann, Beate
AU  - Uhlenbruch, Yasmine
AU  - Dirksen, Uta
TI  - Effect of Radiotherapy Dose on Outcome in Nonmetastatic Ewing Sarcoma.
JO  - Advances in radiation oncology
VL  - 8
IS  - 4
SN  - 2452-1094
CY  - Amsterdam
PB  - Elsevier
M1  - DKFZ-2023-01207
SP  - 101269
PY  - 2023
AB  - Radiation therapy (RT) is an integral part of Ewing sarcoma (EwS) therapy. The Ewing 2008 protocol recommended RT doses ranging from 45 to 54 Gy. However, some patients received other doses of RT. We analyzed the effect of different RT doses on event-free survival (EFS) and overall survival (OS) in patients with EwS.The Ewing 2008 database included 528 RT-admitted patients with nonmetastatic EwS. Recommended multimodal therapy consisted of multiagent chemotherapy and local treatment consisting of surgery (S</td><td width="150">
AB  - RT group) and/or RT (RT group). EFS and OS were analyzed with uni- and multivariable Cox regression models including known prognostic factors such as age, sex, tumor volume, surgical margins, and histologic response.S</td><td width="150">
AB  - RT was performed in 332 patients (62.9
LB  - PUB:(DE-HGF)16
C6  - pmid:37334316
C2  - pmc:PMC10276219
DO  - DOI:10.1016/j.adro.2023.101269
UR  - https://inrepo02.dkfz.de/record/276914
ER  -