%0 Journal Article
%A Eichenauer, Dennis A
%A Bühnen, Ina
%A Baues, Christian
%A Kobe, Carsten
%A Kaul, Helen
%A Greil, Richard
%A Moccia, Alden
%A Zijlstra, Joseé M
%A Hertenstein, Bernd
%A Topp, Max S
%A Just, Marianne
%A von Tresckow, Bastian
%A Eich, Hans-Theodor
%A Fuchs, Michael
%A Dietlein, Markus
%A Hartmann, Sylvia
%A Engert, Andreas
%A Borchmann, Peter
%T Interim PET-guided treatment for early-stage NLPHL: a subgroup analysis of the randomized GHSG HD16 and HD17 studies.
%J Blood
%V 142
%N 6
%@ 0006-4971
%C Washington, DC
%I American Society of Hematology
%M DKFZ-2023-01643
%P 553 - 560
%D 2023
%X The optimal first-line treatment for nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) diagnosed in early stages is largely undefined. We, therefore, analyzed 100 NLPHL patients treated in the randomized HD16 (early-stage favorable; n = 85) and HD17 (early-stage unfavorable; n = 15) studies. These studies investigated the omission of consolidation radiotherapy (RT) in patients with a negative interim positron emission tomography (iPET) (ie, Deauville score <3) after chemotherapy (HD16: 2× doxorubicin, bleomycin, vinblastine, and dacarbazine [ABVD]; HD17: 2× escalated bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone [BEACOPP] plus 2× ABVD). Patients with NLPHL treated in the HD16 and HD17 studies had 5-year progression-free survival (PFS) rates of 90.3
%K Humans
%K Hodgkin Disease: diagnostic imaging
%K Hodgkin Disease: drug therapy
%K Bleomycin: adverse effects
%K Doxorubicin
%K Dacarbazine
%K Vinblastine
%K Antineoplastic Combined Chemotherapy Protocols: adverse effects
%K Cyclophosphamide
%K Vincristine: adverse effects
%K Positron-Emission Tomography: methods
%K Prednisone
%K Bleomycin (NLM Chemicals)
%K Doxorubicin (NLM Chemicals)
%K Dacarbazine (NLM Chemicals)
%K Vinblastine (NLM Chemicals)
%K Cyclophosphamide (NLM Chemicals)
%K Vincristine (NLM Chemicals)
%K Prednisone (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37257195
%R 10.1182/blood.2023019939
%U https://inrepo02.dkfz.de/record/278409