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@ARTICLE{Pham:278646,
      author       = {T. T. Pham and K. Nimptsch and N. Papadimitriou and K.
                      Aleksandrova and M. Jenab and M. J. Gunter and L. Le
                      Marchand and L. Li and B. M. Lynch and S. Castellví-Bel and
                      A. I. Phipps and S. L. Schmit and H. Brenner$^*$ and S.
                      Ogino and E. Giovannucci and T. Pischon},
      title        = {{G}enetically determined circulating resistin
                      concentrations and risk of colorectal cancer: a two-sample
                      {M}endelian randomization study.},
      journal      = {Journal of cancer research and clinical oncology},
      volume       = {149},
      number       = {16},
      issn         = {0301-1585},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DKFZ-2023-01690},
      pages        = {14889-14900},
      year         = {2023},
      note         = {2023 Nov;149(16):14889-14900},
      abstract     = {Resistin, a novel pro-inflammatory protein implicated in
                      inflammatory processes, has been suggested to play a role in
                      colorectal development. However, evidence from observational
                      studies has been inconsistent. Mendelian randomization may
                      be a complementary method to examine this association.We
                      conducted a two-sample Mendelian randomization to estimate
                      the association between genetically determined circulating
                      resistin concentrations and risk of colorectal cancer (CRC).
                      Protein quantitative trait loci (pQTLs) from the SCALLOP
                      consortium were used as instrumental variables (IVs) for
                      resistin. CRC genetic summary data was obtained from
                      GECCO/CORECT/CCFR (the Genetics and Epidemiology of
                      Colorectal Cancer Consortium, Colorectal Cancer
                      Transdisciplinary Study, and Colon Cancer Family Registry),
                      and FinnGen (Finland Biobank). The inverse variance weighted
                      method (IVW) was applied in the main analysis, and other
                      robust methods were used as sensitivity analyses. Estimates
                      for the association from the two data sources were then
                      pooled using a meta-analysis approach.Thirteen pQTLs were
                      identified as IVs explaining together $7.80\%$ of
                      interindividual variation in circulating resistin
                      concentrations. Based on MR analyses, genetically determined
                      circulating resistin concentrations were not associated with
                      incident CRC (pooled-IVW-OR per standard deviation of
                      resistin, 1.01; $95\%$ CI 0.96, 1.06; p = 0.67. Restricting
                      the analyses to using IVs within or proximal to the
                      resistin-encoding gene (cis-IVs), or to IVs located
                      elsewhere in the genome (trans-IVs) provided similar
                      results. The association was not altered when stratified by
                      sex or CRC subsites.We found no evidence of a relationship
                      between genetically determined circulating resistin
                      concentrations and risk of CRC.},
      keywords     = {Colorectal cancer (Other) / Genetic (Other) / Instrumental
                      (Other) / Mendelian randomization (Other) / Resistin
                      (Other)},
      cin          = {C070 / C120 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37599317},
      doi          = {10.1007/s00432-023-05193-0},
      url          = {https://inrepo02.dkfz.de/record/278646},
}