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@ARTICLE{Khan:282516,
      author       = {S. U. Khan and K. Fatima and F. Malik and H. Kalkavan$^*$
                      and A. Wani},
      title        = {{C}ancer metastasis: {M}olecular mechanisms and clinical
                      perspectives.},
      journal      = {Pharmacology $\&$ therapeutics},
      volume       = {250},
      issn         = {0163-7258},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2023-01805},
      pages        = {108522},
      year         = {2023},
      note         = {Volume 250, October 2023, 108522},
      abstract     = {Metastatic progression combined with non-responsiveness
                      towards systemic therapy often shapes the course of disease
                      for cancer patients and commonly determines its lethal
                      outcome. The complex molecular events that promote
                      metastasis are a combination of both, the acquired
                      pro-metastatic properties of cancer cells and a
                      metastasis-permissive or -supportive tumor micro-environment
                      (TME). Yet, dissemination is a challenging process for
                      cancer cells that requires a series of events to enable
                      cancer cell survival and growth. Metastatic cancer cells
                      have to initially detach themselves from primary tumors,
                      overcome the challenges of their intravasal journey and
                      colonize distant sites that are suited for their metastases.
                      The implicated obstacles including anoikis and immune
                      surveillance, can be overcome by intricate intra- and
                      extracellular signaling pathways, which we will summarize
                      and discuss in this review. Further, emerging modulators of
                      metastasis, like the immune-microenvironment, microbiome,
                      sublethal cell death engagement, or the nervous system will
                      be integrated into the existing working model of
                      metastasis.},
      subtyp        = {Review Article},
      keywords     = {Cancer (Other) / Epithelial-mesenchymal transition (EMT)
                      (Other) / Metastasis (Other) / Persister (Other) / Sublethal
                      cell death engagement (Other) / Tumor (immune)
                      micro-environment (Other)},
      cin          = {ED01},
      ddc          = {610},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37661054},
      doi          = {10.1016/j.pharmthera.2023.108522},
      url          = {https://inrepo02.dkfz.de/record/282516},
}