TY  - JOUR
AU  - Tschiderer, Lena
AU  - Peters, Sanne A E
AU  - van der Schouw, Yvonne T
AU  - van Westing, Anniek C
AU  - Tong, Tammy Y N
AU  - Willeit, Peter
AU  - Seekircher, Lisa
AU  - Moreno-Iribas, Conchi
AU  - Huerta, José María
AU  - Crous-Bou, Marta
AU  - Söderholm, Martin
AU  - Schulze, Matthias B
AU  - Johansson, Cecilia
AU  - Själander, Sara
AU  - Heath, Alicia K
AU  - Macciotta, Alessandra
AU  - Dahm, Christina C
AU  - Ibsen, Daniel B
AU  - Pala, Valeria
AU  - Mellemkjær, Lene
AU  - Burgess, Stephen
AU  - Wood, Angela
AU  - Kaaks, Rudolf
AU  - Katzke, Verena
AU  - Amiano, Pilar
AU  - Rodriguez-Barranco, Miguel
AU  - Engström, Gunnar
AU  - Weiderpass, Elisabete
AU  - Tjønneland, Anne
AU  - Halkjær, Jytte
AU  - Panico, Salvatore
AU  - Danesh, John
AU  - Butterworth, Adam
AU  - Onland-Moret, N Charlotte
TI  - Age at Menopause and the Risk of Stroke: Observational and Mendelian Randomization Analysis in 204 244 Postmenopausal Women.
JO  - Journal of the American Heart Association
VL  - 12
IS  - 18
SN  - 2047-9980
CY  - New York, NY
PB  - Association
M1  - DKFZ-2023-01845
SP  - e030280
PY  - 2023
N1  - 2023 Sep 19;12(18):e030280
AB  - Background Observational studies have shown that women with an early menopause are at higher risk of stroke compared with women with a later menopause. However, associations with stroke subtypes are inconsistent, and the causality is unclear. Methods and Results We analyzed data of the UK Biobank and EPIC-CVD (European Prospective Investigation Into Cancer and Nutrition-Cardiovascular Diseases) study. A total of 204 244 postmenopausal women without a history of stroke at baseline were included (7883 from EPIC-CVD [5292 from the subcohort], 196 361 from the UK Biobank). Pooled mean baseline age was 58.9 years (SD, 5.8), and pooled mean age at menopause was 47.8 years (SD, 6.2). Over a median follow-up of 12.6 years (interquartile range, 11.8-13.3), 6770 women experienced a stroke (5155 ischemic strokes, 1615 hemorrhagic strokes, 976 intracerebral hemorrhages, and 639 subarachnoid hemorrhages). In multivariable adjusted observational Cox regression analyses, the pooled hazard ratios per 5 years younger age at menopause were 1.09 (95
KW  - Mendelian randomization analysis (Other)
KW  - age at menopause (Other)
KW  - observational analysis (Other)
KW  - stroke (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37681566
DO  - DOI:10.1161/JAHA.123.030280
UR  - https://inrepo02.dkfz.de/record/282719
ER  -