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@ARTICLE{Demmert:283152,
      author       = {T. T. Demmert$^*$ and K. L. Pomykala and H. Lanzafame$^*$
                      and K. M. Pabst$^*$ and K. Lueckerath$^*$ and J. Siveke$^*$
                      and L. Umutlu and H. Hautzel$^*$ and R. Hamacher$^*$ and K.
                      Herrmann$^*$ and W. P. Fendler$^*$},
      title        = {{O}ncologic {S}taging with 68{G}a-{FAPI} {PET}/{CT}
                      {D}emonstrates a {L}ower {R}ate of {N}onspecific {L}ymph
                      {N}ode {F}indings {T}han 18{F}-{FDG} {PET}/{CT}.},
      journal      = {Journal of nuclear medicine},
      volume       = {64},
      number       = {12},
      issn         = {0097-9058},
      address      = {New York, NY},
      publisher    = {Soc.},
      reportid     = {DKFZ-2023-01938},
      pages        = {1906-1909},
      year         = {2023},
      note         = {2023 Dec 1;64(12):1906-1909},
      abstract     = {Nonspecific lymph node uptake on 18F-FDG PET/CT imaging is
                      a significant pitfall for tumor staging. Fibroblast
                      activation protein α expression on cancer-associated
                      fibroblasts and some tumor cells is less sensitive to acute
                      inflammatory stimuli, and fibroblast activation
                      protein-directed PET may overcome this limitation. Methods:
                      Eighteen patients from our prospective observational study
                      underwent 18F-FDG and 68Ga fibroblast activation protein
                      inhibitor (FAPI) PET/CT scans within a median of 2 d (range,
                      0-22 d). Lymph nodes were assessed on histopathology and
                      compared with SUV measurements. Results: On a per-patient
                      basis, lymph nodes were rated malignant in 10 $(56\%)$
                      versus 7 $(39\%)$ patients by 18F-FDG PET/CT versus
                      68Ga-FAPI PET/CT scans, respectively, with a respective
                      accuracy of $55\%$ versus $94\%$ for true lymph node
                      metastases. Five of 6 $(83\%)$ false-positive nodes on the
                      18F-FDG PET/CT scans were rated true negative by the
                      68Ga-FAPI PET/CT scans. On a per-lesion basis, tumor
                      detection rates were similar (85/89 lesions, $96\%).$
                      Conclusion: 68Ga-FAPI PET/CT imaging demonstrated higher
                      accuracy for true nodal involvement and therefore has the
                      potential to replace 18F-FDG PET/CT imaging for cancer
                      staging.},
      keywords     = {18F-FDG PET/CT (Other) / 68Ga-FAPI PET/CT (Other) / lymph
                      node staging (Other) / oncologic staging (Other)},
      cin          = {ED01},
      ddc          = {610},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37734836},
      doi          = {10.2967/jnumed.123.265751},
      url          = {https://inrepo02.dkfz.de/record/283152},
}