TY  - JOUR
AU  - Wimmers, Florian
AU  - Burrell, Allison R
AU  - Feng, Yupeng
AU  - Zheng, Hong
AU  - Arunachalam, Prabhu S
AU  - Hu, Mengyun
AU  - Spranger, Sara
AU  - Nyhoff, Lindsay E
AU  - Joshi, Devyani
AU  - Trisal, Meera
AU  - Awasthi, Mayanka
AU  - Bellusci, Lorenza
AU  - Ashraf, Usama
AU  - Kowli, Sangeeta
AU  - Konvinse, Katherine C
AU  - Yang, Emily
AU  - Blanco, Michael
AU  - Pellegrini, Kathryn
AU  - Tharp, Gregory
AU  - Hagan, Thomas
AU  - Chinthrajah, R Sharon
AU  - Nguyen, Tran T
AU  - Grifoni, Alba
AU  - Sette, Alessandro
AU  - Nadeau, Kari C
AU  - Haslam, David B
AU  - Bosinger, Steven E
AU  - Wrammert, Jens
AU  - Maecker, Holden T
AU  - Utz, Paul J
AU  - Wang, Taia T
AU  - Khurana, Surender
AU  - Khatri, Purvesh
AU  - Staat, Mary A
AU  - Pulendran, Bali
TI  - Multi-omics analysis of mucosal and systemic immunity to SARS-CoV-2 after birth.
JO  - Cell
VL  - 186
IS  - 21
SN  - 0092-8674
CY  - New York, NY
PB  - Elsevier
M1  - DKFZ-2023-01976
SP  - 4632-4651.e23
PY  - 2023
N1  - 2023 Oct 12;186(21):4632-4651.e23
AB  - The dynamics of immunity to infection in infants remain obscure. Here, we used a multi-omics approach to perform a longitudinal analysis of immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in infants and young children by analyzing blood samples and weekly nasal swabs collected before, during, and after infection with Omicron and non-Omicron variants. Infection stimulated robust antibody titers that, unlike in adults, showed no sign of decay for up to 300 days. Infants mounted a robust mucosal immune response characterized by inflammatory cytokines, interferon (IFN) α, and T helper (Th) 17 and neutrophil markers (interleukin [IL]-17, IL-8, and CXCL1). The immune response in blood was characterized by upregulation of activation markers on innate cells, no inflammatory cytokines, but several chemokines and IFNα. The latter correlated with viral load and expression of interferon-stimulated genes (ISGs) in myeloid cells measured by single-cell multi-omics. Together, these data provide a snapshot of immunity to infection during the initial weeks and months of life.
KW  - SARS-CoV-2 (Other)
KW  - durability (Other)
KW  - infants (Other)
KW  - mucosal immunity (Other)
KW  - multi-omics (Other)
KW  - neonates (Other)
KW  - single-cell ATAC-seq (Other)
KW  - single-cell RNA-seq (Other)
KW  - viral infection (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37776858
DO  - DOI:10.1016/j.cell.2023.08.044
UR  - https://inrepo02.dkfz.de/record/284382
ER  -