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@ARTICLE{Vaupel:284790,
      author       = {P. Vaupel$^*$ and H. Piazena},
      title        = {{H}yperhydration of {C}ancers: {A} {C}haracteristic
                      {B}iophysical {T}rait {S}trongly {I}ncreasing {O}2, {CO}2,
                      {G}lucose and {L}actate {D}iffusivities, and {I}mproving
                      {T}hermophysical {P}roperties of {S}olid {M}alignancies.},
      journal      = {Advances in experimental medicine and biology},
      volume       = {1438},
      issn         = {0065-2598},
      address      = {[Heidelberg]},
      publisher    = {Springer},
      reportid     = {DKFZ-2023-02101},
      isbn         = {978-3-031-42002-3 (print)},
      pages        = {135-145},
      year         = {2023},
      abstract     = {Cancers are complex, heterogeneous, dynamic and aggressive
                      diseases exhibiting a series of characteristic biophysical
                      traits which complement the original biological hallmarks of
                      cancers favouring progressive growth, metastasis, and
                      contributing to immune evasion and treatment resistance. One
                      of the prevalent differences between most solid tumors and
                      their corresponding, healthy tissues is a significantly
                      higher water content (hyperhydration) in cancers. As a
                      consequence, cancers have distinctly higher (Fick's)
                      diffusion coefficients D [cm2 s-1] for the respiratory gases
                      O2 and CO2, the key substrate glucose, and for the
                      oncometabolite lactate. In addition, cancers have (a)
                      clearly increased specific heat capacities cp [J g-1 K-1],
                      thus representing high-capacity-tissues upon therapeutic
                      heating induced by electromagnetic irradiation, and (b)
                      higher thermal conductivities k [W m-1 K-1], i.e., increased
                      abilities to conduct heat. Therefore, in diffusion analyses
                      (e.g., when describing critical O2 and glucose supplies or
                      CO2 removal, and the development of hypoxic subvolumes) and
                      for modeling temperature distributions in hyperthermia
                      treatment planning, these specific cancer-related data must
                      be considered in order to reliably reflect oncologic
                      thermo-radiotherapy settings.},
      keywords     = {Cancer (Other) / Carbon dioxide diffusion coefficient;
                      tumor (Other) / Glucose diffusion coefficient; tumor (Other)
                      / Hyperhydration (Other) / Hyperhydration; tumor (Other) /
                      Lactate diffusion coefficient; cancers (Other) / Ncologic
                      thermo-radiotherapy (Other) / Oxygen diffusion coefficient;
                      tumor (Other) / Oxygen solubility; tumor (Other) / Specific
                      heat capacity; tumor (Other) / Thermal conductivity (Other)
                      / Thermophysical properties; tumor (Other) / Tumor (Other)},
      cin          = {FR01},
      ddc          = {570},
      cid          = {I:(DE-He78)FR01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)3 / PUB:(DE-HGF)16},
      pubmed       = {pmid:37845452},
      doi          = {DOI:10.1007/978-3-031-42003-0_22},
      url          = {https://inrepo02.dkfz.de/record/284790},
}