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@ARTICLE{Seller:285049,
      author       = {A. Seller$^*$ and C. Hackenbruch$^*$ and J. Walz$^*$ and A.
                      Nelde and J. Heitmann$^*$},
      title        = {{L}ong-{T}erm {F}ollow-{U}p of {COVID}-19
                      {C}onvalescents-{I}mmune {R}esponse {A}ssociated with
                      {R}einfection {R}ate and {S}ymptoms.},
      journal      = {Viruses},
      volume       = {15},
      number       = {10},
      issn         = {1999-4915},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2023-02192},
      pages        = {2100},
      year         = {2023},
      abstract     = {SARS-CoV-2 has spread worldwide, causing millions of deaths
                      and leaving a significant proportion of people with
                      long-term sequelae of COVID-19 ('post-COVID syndrome').
                      Whereas the precise mechanism of post-COVID syndrome is
                      still unknown, the immune response after the first infection
                      may play a role. Here, we performed a long-term follow-up
                      analysis of 110 COVID-19 convalescents, analyzing the first
                      SARS-CoV-2-directed immune response, vaccination status,
                      long-term symptoms (approximately 2.5 years after first
                      infection), and reinfections. A total of $96\%$ of
                      convalescents were vaccinated at least once against
                      SARS-CoV-2 after their first infection. A reinfection rate
                      of $47\%$ was observed, and lower levels of anti-spike IgG
                      antibodies after the first infection were shown to associate
                      with reinfection. While T-cell responses could not be
                      clearly associated with persistent postinfectious symptoms,
                      convalescents with long-term symptoms showed elevated
                      SARS-CoV-2-specific antibody levels at the first infection.
                      Evaluating the immune response after the first infection
                      might be a useful tool for identifying individuals with
                      increased risk for re-infections and long-term symptoms.},
      keywords     = {Humans / COVID-19 / Reinfection / SARS-CoV-2 / Follow-Up
                      Studies / Antibodies, Viral / COVID-19 (Other) / SARS-CoV-2
                      (Other) / immune response (Other) / post-COVID syndrome
                      (Other) / Antibodies, Viral (NLM Chemicals)},
      cin          = {TU01},
      ddc          = {050},
      cid          = {I:(DE-He78)TU01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37896879},
      pmc          = {pmc:PMC10611319},
      doi          = {10.3390/v15102100},
      url          = {https://inrepo02.dkfz.de/record/285049},
}