TY  - JOUR
AU  - Rühle, Alexander
AU  - Weymann, Maria
AU  - Behrens, Max
AU  - Marschner, Sebastian
AU  - Haderlein, Marlen
AU  - Fabian, Alexander
AU  - Senger, Carolin
AU  - Dickstein, Daniel R
AU  - Kraft, Johannes
AU  - der Grün, Jens von
AU  - Chen, Eric
AU  - Aquino-Michaels, Todd
AU  - Domschikowski, Justus
AU  - Bickel, Amanda
AU  - Altay-Langguth, Alev
AU  - Kalinauskaite, Goda
AU  - Lewitzki, Victor
AU  - Bonomi, Marcelo
AU  - Blakaj, Dukagjin M
AU  - Jhawar, Sachin R
AU  - Baliga, Sujith
AU  - Barve, Rahul
AU  - Ferentinos, Konstantinos
AU  - Zamboglou, Constantinos
AU  - Schnellhardt, Sören
AU  - Haehl, Erik
AU  - Spohn, Simon K B
AU  - Kuhnt, Thomas
AU  - Zöller, Daniela
AU  - Guckenberger, Matthias
AU  - Budach, Volker
AU  - Belka, Claus
AU  - Bakst, Richard
AU  - Mayer, Arnulf
AU  - Schmidberger, Heinz
AU  - Grosu, Anca-Ligia
AU  - Balermpas, Panagiotis
AU  - Stromberger, Carmen
AU  - Nicolay, Nils
TI  - A Multicenter Evaluation of Different Chemotherapy Regimens in Older Adults With Head and Neck Squamous Cell Carcinoma Undergoing Definitive Chemoradiation.
JO  - International journal of radiation oncology, biology, physics
VL  - 118
IS  - 5
SN  - 0360-3016
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2023-02242
SP  - 1282-1293
PY  - 2024
N1  - 2024 Apr 1;118(5):1282-1293 / #LA:E055#
AB  - The number of older adults with head-and-neck squamous cell carcinoma (HNSCC) is increasing, and treatment of these patients is challenging. Although cisplatin-based chemotherapy concomitantly with radiotherapy is considered standard regimen for patients with locoregionally advanced HNSCC, there is substantial real-world heterogeneity regarding concomitant chemotherapy in older HNSCC patients.The XXX study is an international multicenter cohort study including older (≥65 years) HNSCC patients treated with definitive radiotherapy at 13 academic centers in the United States and Europe. Here, patients with concomitant chemoradiation were analyzed regarding overall survival (OS) and progression-free survival (PFS) using Kaplan-Meier analyses, while Fine-Gray competing risks regressions were performed regarding the incidence of locoregional failures (LRFs) and distant metastases (DMs).Six hundred ninety-seven patients with a median age of 71 years were included in this analysis. Single-agent cisplatin was the most common chemotherapy regimen (n=310; 44
KW  - Radiotherapy (Other)
KW  - carboplatin (Other)
KW  - chemotherapy (Other)
KW  - cisplatin (Other)
KW  - elderly (Other)
KW  - geriatric (Other)
KW  - head and neck cancer (Other)
KW  - mitomycin (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37914144
DO  - DOI:10.1016/j.ijrobp.2023.10.025
UR  - https://inrepo02.dkfz.de/record/285118
ER  -