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@ARTICLE{Ahadova:285255,
      author       = {A. Ahadova$^*$ and A. Stenzinger$^*$ and T. Seppälä and
                      R. Hüneburg and M. Kloor$^*$ and H. Bläker},
      title        = {{T}he two-in-one hit model of the short-cut carcinogenesis
                      of colorectal carcinomas in {MLH}1-associated {L}ynch
                      syndrome. [{D}as {T}wo-in-one-hit-{M}odell der
                      beschleunigten {G}enese von kolorektalen {K}arzinomen beim
                      {MLH}1-assoziierten {L}ynch-{S}yndrom].},
      journal      = {Die Pathologie},
      volume       = {44},
      number       = {Supp. 3},
      issn         = {2731-7188},
      address      = {[Berlin]},
      publisher    = {Springer Medizin Verlag GmbH},
      reportid     = {DKFZ-2023-02290},
      pages        = {188-192},
      year         = {2023},
      note         = {#EA:F210#LA:F210# / 2023 Dec;44(Suppl 3):188-192},
      abstract     = {In a recently published study a new genetic hypothesis was
                      established that explained the existence of CTNNB1 mutations
                      in Lynch syndrome-associated colorectal carcinomas
                      (MLH1-LS-CRC). This hypothesis states that a mitotic
                      recombination on chromosome 3p simultaneously leads to
                      inactivation of the mismatch repair gene MLH1 and to the
                      activation of CTNNB1. This explains the increased frequency
                      of CTNNB1 mutations in MLH1-LS-CRC compared with other colon
                      carcinomas. To test this hypothesis, various experiments
                      were carried out that show that the first phase of
                      recombination occurs in non-cancerous tissues, which favours
                      the development of CTNNB1 mutations. This mechanism could
                      explain the rapid tumour progression in MLH1-LS-CRC. The
                      results highlight the importance of mitotic recombination in
                      carcinogenesis and provide an insight into the genetic basis
                      of colorectal carcinoma in the context of Lynch syndrome.},
      subtyp        = {Review Article},
      keywords     = {Adenoma (Other) / DNA mismatch repair (Other) / Genetic
                      recombination (Other) / Human CTNNB1 protein (Other) / Tumor
                      supressor genes (Other)},
      cin          = {F210 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)F210-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {316 - Infektionen, Entzündung und Krebs (POF4-316)},
      pid          = {G:(DE-HGF)POF4-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37932477},
      doi          = {10.1007/s00292-023-01245-x},
      url          = {https://inrepo02.dkfz.de/record/285255},
}