TY  - JOUR
AU  - Jurmeister, Philipp
AU  - Leitheiser, Maximilian
AU  - Bergmayr, Linda
AU  - Payá Capilla, Emma
AU  - Mochmann, Liliana H
AU  - Zhdanovich, Yauheniya
AU  - Engelhardt-Schott, Fabian
AU  - Schleich, Konstanze
AU  - Klingler, Doreen
AU  - Chimal, Edgar
AU  - Focke, Cornelia M
AU  - Breimer, Gerben E
AU  - van Engen van Grunsven, Ilse
AU  - von Deimling, Andreas
AU  - Capper, David
AU  - Klauschen, Frederick
AU  - Ihrler, Stephan
TI  - Biphasic Myoepithelial Carcinoma With 5p/5q Loss: Morphomolecular Characterization and Provisional Designation of a Proposed Novel Salivary Tumor Entity.
JO  - The American journal of surgical pathology
VL  - 49
IS  - 9
SN  - 0147-5185
CY  - Philadelphia, Pa.
PB  - Lippincott Williams & Wilkins
M1  - DKFZ-2025-01340
SP  - 890-900
PY  - 2025
N1  - 2025 Jul 1;49(9):890-900
AB  - Salivary gland tumors are diagnostically challenging due to major diversity of benign and malignant tumors with enormous intra-tumorous and inter-tumorous heterogeneity and, hence, frequently overlapping histologic features. DNA methylation has greatly enhanced tumor classification in several organs and led to the identification of previously unrecognized entities. In a recent study on DNA methylation of salivary gland tumors, we had identified a group of unclassifiable tumors. In this study, we characterize this group through an integrated analysis of clinical, histomorphologic, immunohistochemical, and molecular features. This group of 12 tumors is characterized by small, clinically benign appearing tumors with striking female predominance (91.7
KW  - 5p/5q loss (Other)
KW  - DNA methylation (Other)
KW  - MDM2 (Other)
KW  - myoepithelial carcinoma (Other)
KW  - salivary gland tumors (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40590272
DO  - DOI:10.1097/PAS.0000000000002450
UR  - https://inrepo02.dkfz.de/record/302800
ER  -