TY  - JOUR
AU  - Vorbach, Samuel M
AU  - Seppi, Thomas
AU  - Peeken, Jan C
AU  - Sarcletti, Manuel
AU  - Pointner, Martin
AU  - Hörmandinger, Katharina
AU  - Mangesius, Julian
AU  - Nevinny-Stickel, Meinhard
AU  - Ganswindt, Ute
TI  - Stereotactic body radiotherapy for single and multiple early-stage non-small cell lung cancer in patients aged ≥ 80 years.
JO  - Radiation oncology
VL  - 20
IS  - 1
SN  - 1748-717X
CY  - London
PB  - BioMed Central
M1  - DKFZ-2025-01441
SP  - 113
PY  - 2025
AB  - Lung cancer primarily affects elderly individuals and is the leading cause of cancer-related death in people aged 80 years and older. In addition, the incidence of multiple primary lung cancer (MPLC) is increasing worldwide. Although surgery is recommended as the standard of care, many elderly patients are considered medically unsuitable, or they refuse surgery. The role of stereotactic body radiotherapy (SBRT) as an alternative treatment option for these elderly patients, particularly those with multiple primary lung cancer, has not been fully elucidated. Therefore, the aim of this study was to report the outcome and toxicities associated with SBRT for histologically confirmed early-stage non-small cell lung cancer (NSCLC) and synchronous and metachronous multiple primary lung cancer in patients aged ≥ 80 years.This retrospective study included 118 patients aged ≥ 80 years with a total of 141 SBRT-treated primary lung cancers (19 patients with MPLC). We assessed local control (LC), progression-free survival (PFS), overall survival (OS) and cancer-specific survival (CSS). We further evaluated toxicities and factors impacting therapeutic efficacy.The median follow-up after SBRT was 47 months (range 3-169 months). The LC rate was 96.2
KW  - Humans
KW  - Aged, 80 and over
KW  - Radiosurgery: methods
KW  - Radiosurgery: adverse effects
KW  - Carcinoma, Non-Small-Cell Lung: pathology
KW  - Carcinoma, Non-Small-Cell Lung: radiotherapy
KW  - Carcinoma, Non-Small-Cell Lung: mortality
KW  - Carcinoma, Non-Small-Cell Lung: surgery
KW  - Lung Neoplasms: pathology
KW  - Lung Neoplasms: radiotherapy
KW  - Lung Neoplasms: mortality
KW  - Lung Neoplasms: surgery
KW  - Female
KW  - Retrospective Studies
KW  - Male
KW  - Survival Rate
KW  - Neoplasms, Multiple Primary: pathology
KW  - Neoplasms, Multiple Primary: radiotherapy
KW  - Neoplasms, Multiple Primary: mortality
KW  - Follow-Up Studies
KW  - Prognosis
KW  - Elderly (Other)
KW  - Lung cancer (Other)
KW  - Multiple primary lung cancer (Other)
KW  - Stereotactic body radiotherapy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40676665
C2  - pmc:PMC12273051
DO  - DOI:10.1186/s13014-025-02693-w
UR  - https://inrepo02.dkfz.de/record/302994
ER  -