TY  - JOUR
AU  - Vogel, Julia
AU  - Luedike, Peter
AU  - Hellhammer, Katharina
AU  - Settelmeier, Stephan
AU  - Jura, Sophia
AU  - Buehning, Florian
AU  - Lerchner, Tobias
AU  - Mondritzki, Thomas
AU  - Carpinteiro, Alexander
AU  - Reinhardt, Annekathrin
AU  - Schindhelm, Florian
AU  - Mahabadi, Amir Abbas
AU  - Rassaf, Tienush
AU  - Michel, Lars
TI  - Safety and Feasibility of Transcatheter Edge-to-Edge Repair of Mitral Regurgitation in Cardiac Amyloidosis.
JO  - JACC: advances
VL  - 4
IS  - 8
SN  - 2772-963X
CY  - [Amsterdam]
PB  - Elsevier B.V.
M1  - DKFZ-2025-01444
SP  - 101998
PY  - 2025
AB  - Cardiac amyloidosis (CA) is characterized by amyloid deposits in the heart leading to various manifestations including heart failure (HF). CA patients often present with severe mitral regurgitation (MR), complicating management in patients. Transcatheter edge-to-edge repair (TEER) offers an interventional option for patients at high surgical risk.The objective of this study was to assess the safety, efficacy, and clinical outcomes of TEER in patients with CA and severe MR.This retrospective study included 27 patients with CA and 81 matched patients with HF without CA and severe MR who underwent TEER. Outcome parameters included technical success, echocardiographic response, laboratory biomarkers, and clinical symptom burden. Follow-up was performed at a median of 103 days (90-144) and included clinical assessment, echocardiography, and laboratory analysis.Patients had a median age of 79 (75-83) years with 86.1
KW  - HFpEF (Other)
KW  - cardiac amyloidosis (Other)
KW  - cardiomyopathy (Other)
KW  - edge-to-edge-repair (Other)
KW  - heart failure (Other)
KW  - mitral regurgitation (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40675021
DO  - DOI:10.1016/j.jacadv.2025.101998
UR  - https://inrepo02.dkfz.de/record/302997
ER  -