% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Andrade:304594,
      author       = {A. F. Andrade and R. Sigaud$^*$ and E. Puligandla and B.
                      Liu and E. Karimi and A. Annett and M. Rezanejad and W.
                      Jawhar and R. Taylor and Y. Cao and S. Schmid$^*$ and F.
                      Selt$^*$ and P. Hernáiz Driever and S. Horn and P.
                      Sievers$^*$ and M. Prinz and M. Glatzel and C. Mawrin and C.
                      Hartmann and C.-M. Monoranu and L. Konnikova and F. Sahm$^*$
                      and S. Pfister$^*$ and O. Witt$^*$ and D. Jones$^*$ and A.
                      Koch and C. L. Kleinman and D. Capper$^*$ and L. Walsh and
                      N. Jabado and T. Milde$^*$},
      title        = {{A} spatial map of {MAPK}-activated immunosuppressive
                      myeloid populations in pediatric low-grade glioma.},
      journal      = {Nature immunology},
      volume       = {26},
      number       = {10},
      issn         = {1529-2908},
      address      = {London},
      publisher    = {Springer Nature Limited},
      reportid     = {DKFZ-2025-01917},
      pages        = {1794-1806},
      year         = {2025},
      note         = {#EA:B310#LA:B310# / 2025 Oct;26(10):1794-1806},
      abstract     = {Pediatric low-grade gliomas (pLGGs) are mitogen-activated
                      protein kinase (MAPK) pathway-activated brain tumors
                      prevalent in children and are associated with morbidity
                      despite favorable survival. Here using imaging mass
                      cytometry, we spatially characterized at the single-cell
                      level the tumor microenvironment (TME) of 120 pLGG cases,
                      considering age, molecular drivers, brain location and tumor
                      subtype. Our analysis identified myeloid cells-including
                      resident microglia and bone marrow-derived macrophages-as
                      the predominant immune population in the TME, particularly
                      in optic pathway tumors. Additionally, we discovered an
                      immune signature predictive of progression-free survival.
                      Spatial analysis identified specific cellular interactions,
                      notably myeloid-myeloid contacts and macrophage-enriched
                      regions harboring MAPK-activated, TIM-3+ myeloid cells,
                      suggesting an immunosuppressive TME. Our study provides a
                      comprehensive resource on the immune landscape of these
                      pLGGs and underscores the immunosuppressive role of diverse
                      myeloid infiltrates. These findings also indicate that
                      combining TIM-3 blockade with MAPK inhibition might be a
                      promising therapeutic strategy to target both the TME and
                      oncogenic MAPK activation in pLGG tumors.},
      cin          = {B310 / HD01 / BE01 / B300 / B062 / B360},
      ddc          = {610},
      cid          = {I:(DE-He78)B310-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)BE01-20160331 / I:(DE-He78)B300-20160331 /
                      I:(DE-He78)B062-20160331 / I:(DE-He78)B360-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40954250},
      doi          = {10.1038/s41590-025-02268-7},
      url          = {https://inrepo02.dkfz.de/record/304594},
}