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000304883 1001_ $$00009-0006-4308-2423$$aAdolph, Louisa$$b0
000304883 245__ $$aClinical and molecular features of primary spinal epidural lymphomas.
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000304883 520__ $$aLymphomas confined to the spinal epidural space at initial diagnosis are rare and referred to as primary spinal epidural lymphoma (PSEL). This study presents clinical, histopathological, and molecular insights from 13 PSEL cases, including follicular lymphoma (PSEL-FL, N = 4), extranodal marginal zone lymphoma (PSEL-MZL, N = 3), diffuse large B-cell lymphoma (PSEL-DLBCL, N = 5), and Burkitt lymphoma (PSEL-BL, N = 1). Despite localized presentation at initial diagnosis, PSEL with aggressive histologies demonstrated remarkably unfavorable outcomes, contrasting the highly indolent clinical course observed in indolent PSEL, particularly PSEL-FL. Molecular analysis showed similarities to nodal counterparts and separation by entity. Comparison of PSEL-FL and classic FL revealed activated tumor microenvironment-associated pathways, potentially supporting extranodal lymphoma growth in this rarely affected spinal epidural site.
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000304883 650_7 $$2Other$$aClinical aspects
000304883 650_7 $$2Other$$aLymphoma
000304883 650_7 $$2Other$$aMolecular analysis
000304883 650_7 $$2Other$$aPathology
000304883 650_7 $$2Other$$aPrimary spinal epidural lymphoma
000304883 7001_ $$00000-0001-6206-0621$$aStoecklein, Veit M$$b1
000304883 7001_ $$00000-0003-4094-1502$$aPasserini, Verena$$b2
000304883 7001_ $$aHeide, Michael$$b3
000304883 7001_ $$00000-0002-1254-5310$$aKarschnia, Philipp$$b4
000304883 7001_ $$aZausinger, Stefan$$b5
000304883 7001_ $$00000-0002-6634-0927$$avon Baumgarten, Louisa$$b6
000304883 7001_ $$0P:(DE-HGF)0$$avon Bergwelt-Baildon, Michael$$b7
000304883 7001_ $$0P:(DE-HGF)0$$aTonn, Jörg Christian$$b8
000304883 7001_ $$00000-0003-0325-4674$$aStoecklein, Sophia$$b9
000304883 7001_ $$00000-0003-0011-5281$$aThon, Niklas$$b10
000304883 7001_ $$00000-0001-6684-3578$$aSchichor, Christian$$b11
000304883 7001_ $$00000-0002-7332-4589$$aRudelius, Martina$$b12
000304883 7001_ $$00000-0002-0987-7373$$aWeigert, Oliver$$b13
000304883 773__ $$0PERI:(DE-600)1458429-3$$a10.1007/s00277-025-06554-0$$pnn$$tAnnals of hematology$$vnn$$x0939-5555$$y2025
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