%0 Journal Article
%A Cakmak, Pinar
%A Lun, Jennifer H
%A Singh, Aakanksha
%A Macas, Jadranka
%A Schupp, Jonathan
%A Schuck, Jonas
%A Mahmoud, Zeina
%A Köhler, Miriam
%A Starzetz, Tatjana
%A Burger, Michael C
%A Steidl, Eike
%A Hasse, Lucie Marie
%A Hattingen, Elke
%A Plate, Karl H
%A Reiss, Yvonne
%A Imkeller, Katharina
%T Spatial immune profiling defines a subset of human gliomas with functional tertiary lymphoid structures.
%J Immunity
%V 58
%N 11
%@ 1074-7613
%C [Cambridge, Mass.]
%I Cell Press
%M DKFZ-2025-02193
%P 2847-2863.e8
%D 2025
%Z 2025 Nov 11;58(11):2847-2863.e8
%X Adult-type diffuse gliomas, the most common primary brain tumors, respond poorly to immune-based therapies and are considered immunologically 'cold' tumors. Here, we examined the features and clinical relevance of glioma intratumoral tertiary lymphoid structures (TLSs) using spatial transcriptome and proteome profiling. In a cohort of 642 gliomas, TLSs were present in 15
%K B cells (Other)
%K adaptive immune receptor repertoire (Other)
%K adult-type diffuse glioma (Other)
%K blood-brain barrier (Other)
%K glioblastoma (Other)
%K immune aggregate (Other)
%K spatial molecular profiling (Other)
%K spatial transcriptomics (Other)
%K tertiary lymphoid structures (Other)
%K tumor immunology (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41125076
%R 10.1016/j.immuni.2025.09.018
%U https://inrepo02.dkfz.de/record/305509