TY  - JOUR
AU  - Cakmak, Pinar
AU  - Lun, Jennifer H
AU  - Singh, Aakanksha
AU  - Macas, Jadranka
AU  - Schupp, Jonathan
AU  - Schuck, Jonas
AU  - Mahmoud, Zeina
AU  - Köhler, Miriam
AU  - Starzetz, Tatjana
AU  - Burger, Michael C
AU  - Steidl, Eike
AU  - Hasse, Lucie Marie
AU  - Hattingen, Elke
AU  - Plate, Karl H
AU  - Reiss, Yvonne
AU  - Imkeller, Katharina
TI  - Spatial immune profiling defines a subset of human gliomas with functional tertiary lymphoid structures.
JO  - Immunity
VL  - 58
IS  - 11
SN  - 1074-7613
CY  - [Cambridge, Mass.]
PB  - Cell Press
M1  - DKFZ-2025-02193
SP  - 2847-2863.e8
PY  - 2025
N1  - 2025 Nov 11;58(11):2847-2863.e8
AB  - Adult-type diffuse gliomas, the most common primary brain tumors, respond poorly to immune-based therapies and are considered immunologically 'cold' tumors. Here, we examined the features and clinical relevance of glioma intratumoral tertiary lymphoid structures (TLSs) using spatial transcriptome and proteome profiling. In a cohort of 642 gliomas, TLSs were present in 15
KW  - B cells (Other)
KW  - adaptive immune receptor repertoire (Other)
KW  - adult-type diffuse glioma (Other)
KW  - blood-brain barrier (Other)
KW  - glioblastoma (Other)
KW  - immune aggregate (Other)
KW  - spatial molecular profiling (Other)
KW  - spatial transcriptomics (Other)
KW  - tertiary lymphoid structures (Other)
KW  - tumor immunology (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41125076
DO  - DOI:10.1016/j.immuni.2025.09.018
UR  - https://inrepo02.dkfz.de/record/305509
ER  -