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@ARTICLE{Cakmak:305509,
      author       = {P. Cakmak and J. H. Lun and A. Singh and J. Macas and J.
                      Schupp and J. Schuck and Z. Mahmoud and M. Köhler and T.
                      Starzetz and M. C. Burger and E. Steidl$^*$ and L. M. Hasse
                      and E. Hattingen$^*$ and K. H. Plate$^*$ and Y. Reiss$^*$
                      and K. Imkeller},
      title        = {{S}patial immune profiling defines a subset of human
                      gliomas with functional tertiary lymphoid structures.},
      journal      = {Immunity},
      volume       = {58},
      number       = {11},
      issn         = {1074-7613},
      address      = {[Cambridge, Mass.]},
      publisher    = {Cell Press},
      reportid     = {DKFZ-2025-02193},
      pages        = {2847-2863.e8},
      year         = {2025},
      note         = {2025 Nov 11;58(11):2847-2863.e8},
      abstract     = {Adult-type diffuse gliomas, the most common primary brain
                      tumors, respond poorly to immune-based therapies and are
                      considered immunologically 'cold' tumors. Here, we examined
                      the features and clinical relevance of glioma intratumoral
                      tertiary lymphoid structures (TLSs) using spatial
                      transcriptome and proteome profiling. In a cohort of 642
                      gliomas, TLSs were present in $15\%$ of tumors and
                      associated with a remodeled perivascular space and spatial
                      redistribution of extracellular matrix components. Three
                      distinct TLS subtypes could be defined based on differing
                      cellular composition and immune activity. While all subtypes
                      lacked classical germinal center architecture, certain TLSs
                      exhibited features of dynamic immune functions, including
                      clonal T and B cell expansion, generation of IgA⁺ and
                      IgG⁺ plasma cells, and dendritic cell-T cell interactions.
                      The presence of TLSs with active immune response features
                      correlated with improved overall survival. Thus, a
                      functional adaptive immune response is detectable in some
                      gliomas, with implications for stratification and
                      treatment.},
      keywords     = {B cells (Other) / adaptive immune receptor repertoire
                      (Other) / adult-type diffuse glioma (Other) / blood-brain
                      barrier (Other) / glioblastoma (Other) / immune aggregate
                      (Other) / spatial molecular profiling (Other) / spatial
                      transcriptomics (Other) / tertiary lymphoid structures
                      (Other) / tumor immunology (Other)},
      cin          = {FM01},
      ddc          = {610},
      cid          = {I:(DE-He78)FM01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41125076},
      doi          = {10.1016/j.immuni.2025.09.018},
      url          = {https://inrepo02.dkfz.de/record/305509},
}