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000305519 041__ $$aEnglish
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000305519 1001_ $$00000-0003-4397-1467$$aWittenstein, Jakob$$b0
000305519 245__ $$aDual-energy computed tomography derived pulmonary blood volume: association with pulmonary blood flow.
000305519 260__ $$aLondon$$bBioMed Central$$c2025
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000305519 520__ $$aDistribution of ventilation and pulmonary perfusion are the major determinants of pulmonary gas exchange. To study and compare strategies of mechanical ventilation in respiratory research accurate and high-resolution methods are needed to derive distribution of ventilation and perfusion with minimal additional intervention or radiation allowing repeated measurements. Dual-energy computed tomography (DECT) is an imaging technique allowing for the derivation of regional pulmonary perfused blood volume, as a surrogate for pulmonary perfusion (PPDECT). Here accuracy of PPDECT is evaluated in comparison to pulmonary blood flow measured with fluorescence-labeled microspheres (PPFLM). Its feasibility of repeated measurements is evaluated.Agreement between PPFLM and PPDECT was assessed by regression as well as Bland-Altman analysis in three anesthetized pigs using DECT and fluorescence labelled microspheres, respectively. Measurements were performed in two-lung and, after right sided thoracotomy, at one-lung ventilation with inhaled nitric oxide. PPFLM and PPDECT were assessed in three different regions of interest (ROI): the right (non-ventilated) and left (ventilated) upper and lower lung, yielding a total of 45 paired measurements over four hours. Persistent iodine accumulation was assessed by additional DECT scans before each contrast administration.Regression analysis revealed a good overall association (R2 = 0.81) between PPFLM and PPDECT, with PPDECT substantially overestimating PPFLM up to 30%, with limits of agreement of -18 and 18%, Low PPFLM was underestimated, while high PPFLM was overestimated by PPDECT, indicating a higher sensitivity of the later. Changes of PPDECT and PPFLM had a concordance of 69.4% for all measurements. Agreement and concordance were highest in ventilated and lowest in non-ventilated ROIs. No persistent iodine enhancement was detected in the lung parenchyma after repetitive measurements per hour.Dual-energy CT based measurement of pulmonary perfusion shows promising results indicating its feasibility in translational research on strategies of mechanical ventilation.
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000305519 650_7 $$2Other$$aDual-energy CT
000305519 650_7 $$2Other$$aFluorescence labelled microspheres
000305519 650_7 $$2Other$$aRegional pulmonary perfusion
000305519 650_7 $$2Other$$aShunt blood flow
000305519 650_2 $$2MeSH$$aAnimals
000305519 650_2 $$2MeSH$$aSwine
000305519 650_2 $$2MeSH$$aPulmonary Circulation: physiology
000305519 650_2 $$2MeSH$$aLung: diagnostic imaging
000305519 650_2 $$2MeSH$$aLung: blood supply
000305519 650_2 $$2MeSH$$aLung: physiology
000305519 650_2 $$2MeSH$$aBlood Volume: physiology
000305519 650_2 $$2MeSH$$aTomography, X-Ray Computed: methods
000305519 650_2 $$2MeSH$$aFemale
000305519 650_2 $$2MeSH$$aRadiography, Dual-Energy Scanned Projection: methods
000305519 650_2 $$2MeSH$$aFeasibility Studies
000305519 7001_ $$aApolle, Rudi$$b1
000305519 7001_ $$aScharffenberg, Martin$$b2
000305519 7001_ $$aRothmann, Carolin$$b3
000305519 7001_ $$aMüller, Sabine$$b4
000305519 7001_ $$aHoffmann, Ralf-Thorsten$$b5
000305519 7001_ $$0P:(DE-He78)91d4b4a1e36e2bec6c08ac43e6820834$$aTroost, Esther$$b6
000305519 7001_ $$aKoch, Thea$$b7
000305519 7001_ $$aGama de Abreu, Marcelo$$b8
000305519 7001_ $$00000-0003-2185-1819$$aHuhle, Robert$$b9
000305519 773__ $$0PERI:(DE-600)2041675-1$$a10.1186/s12931-025-03374-8$$gVol. 26, no. 1, p. 293$$n1$$p293$$tRespiratory research$$v26$$x1465-9921$$y2025
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