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| Home > Publications database > Dual-energy computed tomography derived pulmonary blood volume: association with pulmonary blood flow. > print |
| 001 | 305519 | ||
| 005 | 20251025115556.0 | ||
| 024 | 7 | _ | |a 10.1186/s12931-025-03374-8 |2 doi |
| 024 | 7 | _ | |a pmid:41126267 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC12548200 |2 pmc |
| 024 | 7 | _ | |a 1465-9921 |2 ISSN |
| 024 | 7 | _ | |a 1465-993X |2 ISSN |
| 037 | _ | _ | |a DKFZ-2025-02203 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Wittenstein, Jakob |0 0000-0003-4397-1467 |b 0 |
| 245 | _ | _ | |a Dual-energy computed tomography derived pulmonary blood volume: association with pulmonary blood flow. |
| 260 | _ | _ | |a London |c 2025 |b BioMed Central |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1761309850_2721446 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Distribution of ventilation and pulmonary perfusion are the major determinants of pulmonary gas exchange. To study and compare strategies of mechanical ventilation in respiratory research accurate and high-resolution methods are needed to derive distribution of ventilation and perfusion with minimal additional intervention or radiation allowing repeated measurements. Dual-energy computed tomography (DECT) is an imaging technique allowing for the derivation of regional pulmonary perfused blood volume, as a surrogate for pulmonary perfusion (PPDECT). Here accuracy of PPDECT is evaluated in comparison to pulmonary blood flow measured with fluorescence-labeled microspheres (PPFLM). Its feasibility of repeated measurements is evaluated.Agreement between PPFLM and PPDECT was assessed by regression as well as Bland-Altman analysis in three anesthetized pigs using DECT and fluorescence labelled microspheres, respectively. Measurements were performed in two-lung and, after right sided thoracotomy, at one-lung ventilation with inhaled nitric oxide. PPFLM and PPDECT were assessed in three different regions of interest (ROI): the right (non-ventilated) and left (ventilated) upper and lower lung, yielding a total of 45 paired measurements over four hours. Persistent iodine accumulation was assessed by additional DECT scans before each contrast administration.Regression analysis revealed a good overall association (R2 = 0.81) between PPFLM and PPDECT, with PPDECT substantially overestimating PPFLM up to 30%, with limits of agreement of -18 and 18%, Low PPFLM was underestimated, while high PPFLM was overestimated by PPDECT, indicating a higher sensitivity of the later. Changes of PPDECT and PPFLM had a concordance of 69.4% for all measurements. Agreement and concordance were highest in ventilated and lowest in non-ventilated ROIs. No persistent iodine enhancement was detected in the lung parenchyma after repetitive measurements per hour.Dual-energy CT based measurement of pulmonary perfusion shows promising results indicating its feasibility in translational research on strategies of mechanical ventilation. |
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| 650 | _ | 7 | |a Dual-energy CT |2 Other |
| 650 | _ | 7 | |a Fluorescence labelled microspheres |2 Other |
| 650 | _ | 7 | |a Regional pulmonary perfusion |2 Other |
| 650 | _ | 7 | |a Shunt blood flow |2 Other |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Swine |2 MeSH |
| 650 | _ | 2 | |a Pulmonary Circulation: physiology |2 MeSH |
| 650 | _ | 2 | |a Lung: diagnostic imaging |2 MeSH |
| 650 | _ | 2 | |a Lung: blood supply |2 MeSH |
| 650 | _ | 2 | |a Lung: physiology |2 MeSH |
| 650 | _ | 2 | |a Blood Volume: physiology |2 MeSH |
| 650 | _ | 2 | |a Tomography, X-Ray Computed: methods |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Radiography, Dual-Energy Scanned Projection: methods |2 MeSH |
| 650 | _ | 2 | |a Feasibility Studies |2 MeSH |
| 700 | 1 | _ | |a Apolle, Rudi |b 1 |
| 700 | 1 | _ | |a Scharffenberg, Martin |b 2 |
| 700 | 1 | _ | |a Rothmann, Carolin |b 3 |
| 700 | 1 | _ | |a Müller, Sabine |b 4 |
| 700 | 1 | _ | |a Hoffmann, Ralf-Thorsten |b 5 |
| 700 | 1 | _ | |a Troost, Esther |0 P:(DE-He78)91d4b4a1e36e2bec6c08ac43e6820834 |b 6 |
| 700 | 1 | _ | |a Koch, Thea |b 7 |
| 700 | 1 | _ | |a Gama de Abreu, Marcelo |b 8 |
| 700 | 1 | _ | |a Huhle, Robert |0 0000-0003-2185-1819 |b 9 |
| 773 | _ | _ | |a 10.1186/s12931-025-03374-8 |g Vol. 26, no. 1, p. 293 |0 PERI:(DE-600)2041675-1 |n 1 |p 293 |t Respiratory research |v 26 |y 2025 |x 1465-9921 |
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