% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Vornhlz:305536,
      author       = {M. Vornhülz and S. Sirtl and Y. Xu and S. Klauss and E.
                      Orgler-Gasche and M. Bezmarevic and M. Jovanovic and C.
                      Ricci and M. Fernandez Y Viesca and M. Arvanitakis and A.
                      Hadi and A. P. Prahm and D. Di Mauro and D. A. Ruess$^*$ and
                      C. Focke and F. Bender and J. Hamm and C. Ammer-Herrmenau
                      and T. C. Gonçalves and J. C. Gonçalves and L. Calavrezos
                      and M. Götz and S. Stoerzer and M. Schmelzle and Ł.
                      Nawacki and C. Condori and M. Seitzinger and J. Seelig and
                      S. Chooklin and S. Chuklin and S. Rasch and V. Phillip and
                      S. Pandanaboyana and R. Aljaberi and M. Kuzman and C.
                      Meinhardt and B. González de la Higuera Carnicer and D.
                      Ruiz-Clavijo García and B. Eross and P. Hegyi and N.
                      Kerbazh and T. V. Moga and K. Pawlak and N. Calo and K.
                      Khalaf and M. Brunner and L. Schulte and A. Kleger and M. L.
                      Ruiz Rebollo and M. Seidensticker and M. Wildgruber and U.
                      Mansmann and H. Stubbe and J. Mayerle and G. Beyer},
      collaboration = {V. R. DRACULA study group: Laszlo Czako},
      title        = {{C}ommon {P}ractice of {P}ercutaneous {D}rainage in
                      {N}ecrotising {P}ancreatitis-{A} {M}ulticentre
                      {R}etrospective {S}tudy ({DRACULA}).},
      journal      = {United european gastroenterology journal},
      volume       = {nn},
      issn         = {2050-6406},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DKFZ-2025-02210},
      pages        = {nn},
      year         = {2025},
      note         = {epub},
      abstract     = {Acute necrotising pancreatitis carries high mortality,
                      especially if infected necrosis occurs. While percutaneous
                      drainage may be required when internal drainage is not
                      feasible, reliable guidelines for managing percutaneous
                      drains are lacking. This study aimed to assess the common
                      practice of percutaneous drainage therapy for infected
                      pancreatic necrosis.This retrospective study among 29
                      tertiary care centres included all patients hospitalised for
                      necrotising acute pancreatitis from 01/2016 until 12/2022
                      with at least one percutaneous drain. The length of hospital
                      stay was the primary endpoint, with mortality as the
                      secondary endpoint. Between-group comparisons were conducted
                      using the ratio of restricted mean survival time (RMST)
                      after adjusting for confounders.585 patients $(67\%$ male)
                      from 29 tertiary care centres in 15 countries in Europe,
                      Canada and Bolivia were included in the analysis. Length of
                      hospitalisation or mortality did not differ between the
                      flushed (n = 398) and non-flushed groups (RMST ratio 1.04,
                      p-value = 0.42 and RMST ratio 1.05, p-value = 0.1
                      respectively). Mortality was significantly lower in those
                      patients who received a combination of percutaneous and
                      internal drains (dual-modality drainage, n = 243) as
                      compared to those who received percutaneous drains only
                      (RMST ratio 1.05, p-value = 0.01). Flushing with antibiotics
                      as compared to saline was not associated with shorter length
                      of hospital stay or lower mortality (RMST ratio 0.98,
                      p-value = 0.78 and 0.97, p-value = 0.48 respectively).This
                      study reveals notable differences in therapeutic concepts
                      and flushing management for percutaneous drains. While
                      flushing itself was not associated with a shorter length of
                      hospitalisation or lower in-hospital mortality, a lower
                      mortality was observed when internal and percutaneous
                      drainage were used in combination.The study was
                      prospectively registered in the German Clinical Trials
                      Register (Deutsches Register Klinischer Studien, DRKS) under
                      the registration number DRKS00032231.},
      keywords     = {drainage (Other) / flushing (Other) / necrosis (Other) /
                      pancreatitis (Other)},
      cin          = {FR01},
      ddc          = {610},
      cid          = {I:(DE-He78)FR01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41137746},
      doi          = {10.1002/ueg2.70133},
      url          = {https://inrepo02.dkfz.de/record/305536},
}