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000305537 1001_ $$0P:(DE-HGF)0$$aTeske, Nico$$b0
000305537 245__ $$aAssociations of supramaximal resection with outcome in glioblastoma across age groups: a report of the RANO resect group.
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000305537 520__ $$aThe oncological role of resection in elderly patients with glioblastoma remains controversial. We evaluated the value of resection in patients ≥65 years with (I) newly diagnosed and (II) recurrent glioblastoma by comparing the prognostic relevance of extent of resection to patients <65 years.The international RANO resect group retrospectively collected patients with newly diagnosed and recurrent IDH-wildtype glioblastoma from ten neuro-oncological centers. Associations of residual tumor with molecular and clinical markers and survival were analyzed.1260 patients with newly diagnosed glioblastoma were identified, including 512 patients ≥65 years. Lower postoperative contrast-enhancing tumor volumes were favorably associated with survival on uni- and multivariate analyses; however, the associations with outcome were more pronounced in younger patients. Only in patients <65 years, supramaximal resection was associated with more favorable survival (40 vs. 20 months, p=0.001). In 310 patients with first recurrence (≥65 years: 92), maximal resection of contrast-enhancing tumor was associated with favorable outcomes, particularly in younger patients. Neither older nor younger patients had favorable outcome associations of supramaximal resection in the recurrent setting. All findings were confirmed in propensity-score-matched analyses to minimize confounding effects of inherent differences in demographic and clinical markers (including second-line treatments) between older and younger patients.While complete contrast-enhancing tumor resection is prognostic for favorable outcomes in older patients, associations of supramaximal resection with improved outcomes were only retained in younger patients with newly diagnosed disease. Those findings support stratified surgical approaches.
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000305537 650_7 $$2Other$$aextent of resection
000305537 650_7 $$2Other$$aglioblastoma
000305537 650_7 $$2Other$$aoutcome
000305537 650_7 $$2Other$$apatient stratification
000305537 650_7 $$2Other$$asurgery
000305537 7001_ $$aDono, Antonio$$b1
000305537 7001_ $$aYoung, Jacob S$$b2
000305537 7001_ $$aJuenger, Stephanie T$$b3
000305537 7001_ $$aYoussef, Gilbert C$$b4
000305537 7001_ $$aHäni, Levin$$b5
000305537 7001_ $$aSciortino, Tommaso$$b6
000305537 7001_ $$aBruno, Francesco$$b7
000305537 7001_ $$aDietrich, Jorg$$b8
000305537 7001_ $$aMau, Christine Y$$b9
000305537 7001_ $$aWeller, Michael$$b10
000305537 7001_ $$aBeck, Juergen$$b11
000305537 7001_ $$aHervey-Jumper, Shawn$$b12
000305537 7001_ $$aMolinaro, Annette M$$b13
000305537 7001_ $$aChang, Susan M$$b14
000305537 7001_ $$avan den Bent, Martin$$b15
000305537 7001_ $$aVogelbaum, Michael A$$b16
000305537 7001_ $$aRuge, Maximilian I$$b17
000305537 7001_ $$aCahill, Daniel P$$b18
000305537 7001_ $$aRudà, Roberta$$b19
000305537 7001_ $$aBello, Lorenzo$$b20
000305537 7001_ $$aGrau, Stefan J$$b21
000305537 7001_ $$aSchnell, Oliver$$b22
000305537 7001_ $$aHuang, Raymond Y$$b23
000305537 7001_ $$aWen, Patrick Y$$b24
000305537 7001_ $$aTandon, Nitin$$b25
000305537 7001_ $$aBerger, Mitchel S$$b26
000305537 7001_ $$0P:(DE-HGF)0$$aTonn, Joerg-Christian$$b27
000305537 7001_ $$aEsquenazi, Yoshua$$b28
000305537 7001_ $$0P:(DE-HGF)0$$aKarschnia, Philipp$$b29
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