%0 Journal Article
%A Bill, Marius
%A Eckardt, Jan-Niklas
%A Döhner, Konstanze
%A Röhnert, Maximillian-Alexander
%A Rausch, Christian
%A Metzeler, Klaus H
%A Spiekermann, Karsten
%A Stasik, Sebastian
%A Wurm, Alexander Arthur
%A Sauer, Tim
%A Scholl, Sebastian
%A Schnetzke, Ulf
%A Hochhaus, Andreas
%A Crysandt, Martina
%A Brümmendorf, Tim H
%A Krug, Utz
%A Wörmann, Bernhard
%A Einsele, Hermann
%A Hiddemann, Wolfgang
%A Görlich, Dennis
%A Sauerland, Cristina
%A Steffen, Björn
%A Neubauer, Andreas
%A Burchert, Andreas
%A Schäfer-Eckart, Kerstin
%A Berdel, Wolfgang E
%A Schliemann, Christoph
%A Krause, Stefan W
%A Hänel, Mathias
%A Hanoun, Maher
%A Kaufmann, Martin
%A Fransecky, Lars
%A Braess, Jan
%A Schetelig, Johannes
%A Middeke, Jan Moritz
%A Bullinger, Lars
%A Heuser, Michael
%A Thol, Felicitas
%A Serve, Hubert
%A Baldus, Claudia D
%A Platzbecker, Uwe
%A Müller-Tidow, Carsten
%A Válka, Jan
%A Šrámek, Jiří
%A Weinbergerova, Barbora
%A Mayer, Jiri
%A Dumas, Pierre-Yves
%A Bertoli, Sarah
%A Delabesse, Eric
%A Récher, Christian
%A Pigneux, Arnaud
%A Herold, Tobias
%A Ganser, Arnold
%A Döhner, Hartmut
%A Bornhäuser, Martin
%A Thiede, Christian
%A Röllig, Christoph
%T Differential prognostic impact of myelodysplasia-related gene mutations in a European cohort of 4978 intensively treated AML patients.
%J Leukemia
%V nn
%@ 0887-6924
%C London
%I Springer Nature
%M DKFZ-2025-02214
%P nn
%D 2025
%Z epub
%X In the European LeukemiaNet (ELN) 2022 recommendations, myelodysplasia-related (MR) gene mutations were classified as a novel adverse prognostic category for intensively treated acute myeloid leukemia (AML). To assess the prognostic impact of individual MR genes within the ELN, clinical, cytogenetic, and molecular data from 4,978 intensively treated AML patients were analyzed. Remission rates and survival outcomes were evaluated. For analyses in context of ELN2022 classification, patients carrying an MR mutation were excluded from the adverse group and analyzed separately; those with co-occurring favorable or intermediate features remained in their respective groups. Overall, 1698 patients (34.1
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41145671
%R 10.1038/s41375-025-02781-6
%U https://inrepo02.dkfz.de/record/305540